MACROMOLECULAR DESIGN OF NEW SYNTHETIC BIODEGRADABLE MEDICAL POLYMERS: Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences

机译：新型合成生物可降解医用聚合物的大分子设计：功能性聚酯和具有细胞粘附肽序列的共聚物

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Biodegradable polymers with functional groups can be prepared through copolymerization of lactones and functional hydroxy acid and a-amino acid derivatives. Statistical copolymers with pendant carboxylic aid or amine groups can be prepared. Block copolymers containing poly(hydroxy acid) and poly(α-amino acid) blocks can be prepared by stepwise application of controlled ring-opening polymerizations of NCAs and lactones. Biospecific peptide sequences can be introduced into the polymer structure either by biding through pendant functional groups in the side chains or as a peptide segment in block copolymers. Stra egy of using amphiphilic block copolymers for designing biospecific polymer surfaces is presented.

机译：具有官能团的可生物降解的聚合物可以通过内酯与官能羟基酸和α-氨基酸衍生物的共聚来制备。可以制备具有侧链羧酸助剂或胺基的统计共聚物。包含聚（羟基酸）和聚（α-氨基酸）嵌段的嵌段共聚物可以通过逐步施加NCA和内酯的受控的开环聚合反应来制备。可通过穿过侧链中的侧链官能团或作为嵌段共聚物中的肽段，将生物特异性肽序列引入聚合物结构中。提出了使用两亲嵌段共聚物设计生物特异性聚合物表面的策略。

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《NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration Oct 15-25, 2001 Alvor, Algarve, Portugal》|2001年|p.167-182|共16页
会议地点 Alvor Algarve Portugal
作者
F. RYPACEK;
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作者单位

Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
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1. Biodegradable copolymers carrying cell-adhesion peptide sequences. [J] . Proks V, Machova L, Popelka S, Advances in Experimental Medicine and Biology . 2003,第0期

机译：带有细胞粘附肽序列的可生物降解的共聚物。
2. Biodegradable synthetic polymers: Preparation, functionalization and biomedical application [J] . Huayu Tian, Zhaohui Tang, Xiuli Zhuang Progress in Polymer Science . 2012,第2期

机译：可生物降解的合成聚合物：制备，功能化和生物医学应用
3. Peptide-Directed Self-Assembly of Functionalized Polymeric Nanoparticles Part I:Design and Self-Assembly of Peptide- Copolymer Conjugates into Nanoparticle Fibers and 3D Scaffolds [J] . Xiaochu Ding, Jagadeesh Janjanam, Ashutosh Tiwari, Macromolecular bioscience . 2014,第6期

机译：功能化聚合物纳米粒子的肽导向自组装第一部分：肽共聚物共轭到纳米粒子纤维和3D支架中的设计和自组装
4. MACROMOLECULAR DESIGN OF NEW SYNTHETIC BIODEGRADABLE MEDICAL POLYMERS: Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences [C] . F. RYPACEKauthor_name/, NATO NATO advanced study conference on polymer based systems on tissue engineering, replacement and regeneration . 2002

机译：新型合成生物降解的医用聚合物的大分子设计：功能性聚酯和具有细胞粘附肽序列的功能性聚酯和共聚物
5. The synthesis and characterization of novel biomaterials from natural building blocks: Biomaterials research: Past, present, and future directions, and, Saccharide-derived polymers as protein resistant biomaterials, and, Saccharide-peptide copolymers for gene delivery applications, and, Saccharide-peptide copolymer hydrogels for extracellular scaffold design. [D] . Metzke, Mark Adam. 2006

机译：从天然构件中合成和表征新型生物材料：生物材料研究：过去，现在和未来的方向，以及，糖衍生的聚合物作为抗蛋白质生物材料，以及用于基因传递应用的糖肽共聚物，以及糖肽共聚物水凝胶用于细胞外支架设计。
6. Macromolecular Design via an Organocatalytic Monomer-Specificand Temperature-Dependent On/Off Switch. High PrecisionSynthesis of Polyester/Polycarbonate Multiblock Copolymers [O] . Peter Olsén, Karin Odelius, Helmut Keul, -1

机译：通过有机催化单体特异性的大分子设计和取决于温度的开/关开关。高精准度聚酯/聚碳酸酯多嵌段共聚物的合成
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机译：Lacoca和Manoca的无定形随机共聚物，用于设计可变性能的可生物降解的聚酯

MACROMOLECULAR DESIGN OF NEW SYNTHETIC BIODEGRADABLE MEDICAL POLYMERS: Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences

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