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首页> 外文会议>NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration Oct 15-25, 2001 Alvor, Algarve, Portugal >BIODEGRADABLE POLYMERS AS SCAFFOLDS FOR TISSUE ENGINEERING AND AS TISSUE REGENERATION INDUCERS
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BIODEGRADABLE POLYMERS AS SCAFFOLDS FOR TISSUE ENGINEERING AND AS TISSUE REGENERATION INDUCERS

机译：生物可降解聚合物作为组织工程的支架和组织再生的诱导剂

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摘要

The most powerful treatment to cure diseases may be medication, that is, drug administration to the patients. However, drugs are no more effective when large part of a tissue has been severely damaged or an organ has irreversibly lost its function. In these cases, either artificial organ or organ transplantation is at present the first choice for reconstruction of the defective or lost organ. Unfortunately, these therapeutic methods are not always effective, but have several problems that are difficult to solve. For instance, the number of organ donors is quite smaller than that of the patients waiting for the organ to be transplanted. Complications of immuno-suppresive agents are also trouble for the organ recipients. Also, current artificial organs arc required to improve the poor biocompatibility and the insufficient ability to replace defective organs. Recently, a new therapeutic means has emerged to complement this reconstructive surgery supported by the artificial organs and the organ transplantation. That is the regenerative medicine which is characterized by tissue regeneration mostly using autologous cells. If a new tissue is regenerated from the cells of patient herself or himself to replace a defective tissue, this regenerated tissue is absolutely free of immune rejection and foreign-body reaction, because the tissue is autologous. Therefore, the regenerative medicine is often called ultimate ideal means for reconstructive medicine.
机译：治愈疾病最有效的方法可能是药物治疗，即对患者给药。但是，当大部分组织严重受损或器官不可逆转地丧失功能时，药物不再有效。在这些情况下，人工器官或器官移植目前是重建有缺陷或丢失的器官的首选。不幸的是，这些治疗方法并不总是有效的，但是存在一些难以解决的问题。例如，器官供体的数量比等待器官移植的患者的数量要少得多。免疫抑制剂的并发症也给器官接受者带来麻烦。而且，需要当前的人工器官来改善不良的生物相容性和不足的替换缺陷器官的能力。近来，出现了新的治疗手段来补充由人工器官和器官移植支持的这种重建手术。那是一种再生药物，其特征是主要使用自体细胞进行组织再生。如果从患者本人或他自己的细胞再生出新的组织来替换有缺陷的组织，则该再生的组织绝对没有免疫排斥和异物反应，因为该组织是自体的。因此，再生医学通常被称为重建医学的最终理想手段。

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