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首页> 外文会议>NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration Oct 15-25, 2001 Alvor, Algarve, Portugal >SCAFFOLDING ARTERIAL TISSUE
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SCAFFOLDING ARTERIAL TISSUE

机译：脚手架动脉组织

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The remarkable progress made in Biomaterials Science, witnessed during the last two decades, has made possible the development of a diversity of biomedical systems, which have contributed significantly to modern medicine. Nevertheless, only a new generation of devices, based on novel tailor made materials and new engineering and biological concepts, will permit further progress. Developing a new vascular graft is a multifaceted challenge where hemocompatibility, porosity and compliance requirements must be organically integrated into the prosthesis design. By capitalizing on the advantages of Composite Materials and by choosing the appropriate material combination, a variety of new vascular grafts were produced, exhibiting gradually increasing porosity and mechanical properties akin to those of natural arteries. Due to its enhanced hydrophilicity, the PELA-rich mural composition attained high water uptake levels, resulting in a prosthesis which combined tissue like soft consistency and the high compliance with the enhanced strength provided by the elastomeric scaffold. The selectivel) biodegradable graft resulted in excellent healing and incorporation processes, this being fully corroborated by histological studies. It was also surmised that PELA played an important role, not only as the gradually degrading sealant of the graft, but also by minimizing its surface thrombogenicity.
机译：在过去的二十年中见证了生物材料科学领域的显着进步，这使得多种生物医学系统的发展成为可能，这为现代医学做出了重大贡献。但是，只有基于新颖的量身定制的材料以及新的工程和生物学概念的新一代设备才能取得进一步的进步。开发新的血管移植物是多方面的挑战，必须将血液相容性，孔隙率和顺应性要求有机地整合到假体设计中。通过利用复合材料的优势并通过选择合适的材料组合，可以生产出多种新型的血管移植物，它们的孔隙率和机械性能逐渐增加，类似于天然动脉。由于其增强的亲水性，富含PELA的壁组合物达到了较高的吸水率，从而形成了一种假体，该假体结合了诸如软稠度之类的组织，并且高度顺应了弹性体支架所提供的增强强度。可选择性生物降解的移植物具有出色的愈合和整合过程，这在组织学研究中得到了充分证实。还据推测，PELA不仅起着逐渐降解移植物的密封剂作用，而且还通过最小化其表面血栓形成性发挥了重要作用。

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