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Diffusion NMR of Polymers in Bicelles

机译:核磁共振聚合物在单元格中的扩散。

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摘要

This mini-review describes diffusion NMR studies of polymers in bicelles using the pulsed field gradient (PFG) NMR technique. Bicelles are first introduced and their morphology and applications as membrane mimetics and confinement media are briefly covered. The PFG NMR diffusion method is then introduced, emphasizing its specific advantages and limitations when applied to diffusion measurements in macroscopically-oriented lamellar systems such as magnetically-aligned bicelles. The utility of PFG NMR diffusion measurements in bicellar model membrane systems for examining lateral diffusion of membrane-bound, surface-grafted poly(ethylene glycol) (PEG) molecular species is demonstrated, focusing on those features of lateral diffusion and / or bicelle morphology that such studies illuminate. Further, PFG NMR diffusion studies of various molecular weight soluble PEG species confined within the parallel-plate geometry of magnetically aligned bicelles are reviewed, again focusing on revelations concerning bicelle morphology. The discussion concludes with an outline of future prospects for diffusion NMR studies in bicelles.
机译:这份小型综述描述了使用脉冲场梯度(PFG)NMR技术对聚合物在双室中的扩散NMR研究。首先介绍了Bicell,并简要介绍了它们的形态和应用,如膜模拟物和限制介质。然后介绍了PFG NMR扩散方法,强调了其在应用于宏观取向的层状系统(例如,磁对准的Bicell)中进行扩散测量时的特定优点和局限性。展示了PFG NMR扩散测量在双室模型膜系统中用于检查膜结合的,表面接枝的聚(乙二醇)(PEG)分子种类的侧向扩散的实用性,重点是侧向扩散和/或比塞勒形态的那些特征,这样的研究很有启发性。此外,审查了局限在磁性排列的双胞胎的平行板几何形状内的各种分子量可溶性PEG种类的PFG NMR扩散研究,再次重点关注了有关比塞尔形态的揭示。讨论结束时概述了单细胞内扩散NMR研究的未来前景。

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