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首页> 外文会议>NMR spectroscopy of polymers: Innovative strategies for complex macromolecules >Effect of Molecular Architecture on the Performance of ~(19)F NMR Imaging Agents
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Effect of Molecular Architecture on the Performance of ~(19)F NMR Imaging Agents

机译：分子结构对〜（19）F NMR成像剂性能的影响

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摘要

Traditional magnetic resonance medical imaging agents based on paramagnetic ions or particles have a number of critical limitations, namely image contrast is often limited at low concentrations and sensitivity of the agents becomes diminished at higher magnetic field strengths. In this chapter we describe the development of a new class of polymeric imaging agent which relies on direct detection of the NMR signal of fluorine nuclei and hence circumvents these potential problems. The imaging performance of the new materials relies on the maintenance of librational motion of the fluorinated segments, necessary for partial averaging of the otherwise strong dipole-dipole interactions and large chemical shift interactions of the ~(19)F nuclei. The performance of partially-fluorinated block copolymers assembled into particles is described and related to the interactions of the polymer chains with the surrounding solvent medium. A second generation of materials based on a hyperbranched structure was developed based on the learning obtained from the earlier experiments and these demonstrated excellent in vitro and in vivo imaging performance.
机译：基于顺磁性离子或颗粒的传统磁共振医学成像剂具有许多关键的局限性，即，在低浓度下图像对比度常常受到限制，而在较高的磁场强度下，试剂的灵敏度会降低。在这一章中，我们描述了一种新型的聚合物显像剂的开发，它依赖于直接检测氟核的NMR信号，从而避免了这些潜在的问题。新材料的成像性能依赖于维持氟化链段的自由运动，这对于部分平均〜（19）F核的强偶极-偶极相互作用和大化学位移相互作用是必不可少的。描述了组装成颗粒的部分氟化嵌段共聚物的性能，并与聚合物链与周围溶剂介质的相互作用有关。基于从早期实验中获得的经验，开发了基于超支化结构的第二代材料，这些材料展示了出色的体外和体内成像性能。

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  • 会议地点 Honolulu HI(US);Honolulu HI(US)
  • 作者

    Hui Peng; Kristofer Thurecht; Steven Hsu; Idriss Blakey; Oliver Squires; Nyoman Kurniawan; Stephen Rose; Andrew K Whittaker;

  • 作者单位

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

    Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, University of Queensland,Brisbane, QLD 4072, Australia;

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  • 正文语种 eng
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