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首页> 外文会议>Nonimaging optics: Efficient design for illumination and solar concentration VIII >Illumination devices for uniform delivery of light to the oral cavity for photodynamic therapy
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Illumination devices for uniform delivery of light to the oral cavity for photodynamic therapy

机译：照明装置，用于将光均匀地传递到口腔以进行光动力疗法

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摘要

To date, the lack of light delivery mechanisms to the oral cavity remains a barrier to the treatment of oral cancer with photodynamic therapy (PDT). The greatest impediment to medical practitioners is the current need to shield the normal tissues of the oral cavity, a costly and time-consuming procedure. In this research, we present the design of illumination devices to deliver light to the oral cavity for PDT, which will facilitate administration of PDT in the clinic. The goal for such an illumination device, as indicated by our clinical collaborators at Roswell Park Cancer Institute in Buffalo, NY, is to limit exposure of healthy tissue and produce an average irradiance of 100 mW/cm~2 over the treatment field, with spatial non-uniformities below 10%. Furthermore, the size of the device must be compact to allow use in the oral cavity. Our research led to the design and fabrication of two devices producing spatial non-uniformities below 6% over a treatment area of 0.25 cm~2 by design. One device consisted of an appropriately-sized reflector, inspired by solar concentrators, illuminated by a cylindrical diffusing fiber optimally located within the reflector; another was a solid lightpipe with a combination of optimized tapered and straight components.
机译：迄今为止，缺乏向口腔的光传递机制仍然是光动力疗法（PDT）治疗口腔癌的障碍。对医学从业者的最大障碍是当前需要保护口腔的正常组织，这是昂贵且费时的过程。在这项研究中，我们提出了照明设备的设计，以将光传递到口腔中以进行PDT，这将有助于临床中PDT的管理。正如纽约州布法罗市罗斯韦尔公园癌症研究所的临床合作者所指出的，这种照明设备的目标是限制健康组织的暴露，并在整个治疗范围内产生100 mW / cm〜2的平均辐照度，并且具有空间不均匀度低于10％。此外，装置的尺寸必须紧凑以允许在口腔中使用。我们的研究导致设计和制造了两种器件，这些器件通过设计在0.25 cm〜2的处理面积上产生低于6％的空间不均匀性。一种设备由适当大小的反射器组成，该反射器受太阳能聚光器的启发，并由最佳位于反射器内的圆柱状漫射纤维照明。另一个是结合了优化的锥形和笔直组件的实心光导管。

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