Preparation and in Vitro Evaluation of Trimebutine Maleate Gastric Floating Sustained-release Tablets

机译：马来酸曲美布汀胃漂浮缓释片的制备及体外评价

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Trimebutine maleate gastric floating sustained-release tablets was prepared via direct compression. Its release rate and floating properties were determined and compared by the traditional basket method and the improved method. When the flow rate of peristaltic pump was 2.2ml·min-1 and rotation speed was 50r·min-1, the accumulative release profile of two methods was quite similar and obeyed Ritger-Peppas equation. The initial floating time and durative floating time was both 5 seconds and 12 hours respectively. Two methods can be utilized to control its quality in vitro, while the improved method can mimic conditions in vivo and has no negative effect on observing floating time visually.

机译：通过直接压制制备马来酸曲美布汀胃漂浮缓释片。用传统的篮子法和改进的方法测定并比较了其释放速率和漂浮性能。当蠕动泵的流量为2.2ml·min-1且转速为50r·min-1时，两种方法的累积释放曲线非常相似，并遵循Ritger-Peppas方程。初始浮动时间和持续浮动时间分别为5秒和12小时。可以采用两种方法在体外控制其质量，而改进的方法可以模拟体内条件，并且对目视观察漂浮时间没有负面影响。

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来源
《Novel Drug Delivery Systems: Research and Application》|2007年|77-81|共5页
会议地点 Shanghai(CN)
作者
Keyi WANG; rnShuang ZHANG; rnYanrui DONG;
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作者单位

LIU Yuan-Jiang@Tongji College of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030;

Hubei Antiviral Drugs Key Laboratory, Hubei Livscien Pharm Sci Tech Co. Ltd., Wuhan 430061--LI Gao@Tongji College of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030--SHEN Ling-Jia@Hubei Antiviral Drugs Key Laboratory, Hubei Livscien Pharm Sci Tech Co. Ltd., Wuhan 430061--LIU Hong@Hubei Antiviral Drugs Key Laboratory, Hubei Livscien Pharm Sci Tech Co. Ltd., Wuhan 430061--;

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会议组织
原文格式 PDF
正文语种 eng
中图分类药剂学;
关键词
trimebutine maleate; sustained-release tablets; floating properties; similarity factor;

机译：马来酸曲美布汀;缓释片;漂浮性能;相似因子;

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Preparation and in Vitro Evaluation of Trimebutine Maleate Gastric Floating Sustained-release Tablets

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