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Preparation and evaluation of flurbiprofen patch

机译：氟比洛芬贴剂的制备与评价

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摘要

Objective: To prepare and evaluate of flurbiprofen patch. Methods: The flurbiprofen patch was prepared with polyisobutylene as pressure sensitive adhesive. The RP-HPLC method was applied to determine flurbiprofen content. The in vitro release characteristics, cohesive force and adhesive force were studied according to reporting methods in literature. 87 patients with different pain were selected to evaluate the effect of flurbiprofen patch. Results: The average content of flurbiprofen patch was 0.487mg/cm2 (RSD 7.34%), the release mechanisms of flurbiprofen patch in vitro coincided with first equation ln (1-Mt/M∞)=0.171-0.105t (r=0.999); 68 patients were effective with total effective rate 78.2%, especially more effective to knee joint pain. Conclusion: Flurbiprofen patch provides an effective therapeutic selection for the pain clinic.
机译：目的：制备和评价氟比洛芬贴剂。方法：以聚异丁烯为压敏胶制备氟比洛芬贴剂。采用RP-HPLC法测定氟比洛芬含量。根据文献报道方法研究了体外释放特性，内聚力和粘附力。选择87例不同疼痛的患者来评估氟比洛芬贴剂的疗效。结果：氟比洛芬贴剂的平均含量为0.487mg / cm2（RSD 7.34％），氟比洛芬贴剂的体外释放机理与第一方程ln（1-Mt /M∞）= 0.171-0.105t（r = 0.999）吻合。 ; 68例患者有效率，总有效率为78.2％，尤其对膝关节疼痛有效。结论：氟比洛芬贴剂可为疼痛临床提供有效的治疗选择。

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  • 来源
  • 会议地点 Shanghai(CN)
  • 作者

    Jie SHEN;

  • 作者单位

    ZHU quan-gang@Department of Pharmacy--HU jin-hong@Department of Pharmacy--Lu song-wei@Department of Pharmacy--Liu shao-ming@Department of Pharmacy--Zou wen-yi@Department of Anesthesiology, Second Military Medical University, Shanghai 200433, China--WANG jin-yang@Department of Anesthesiology, Second Military Medical University, Shanghai 200433, China--;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药剂学;
  • 关键词

    Flurbiprofen; Patch; Pain;

    机译：氟比洛芬;贴剂;疼痛;

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