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首页> 外文会议>Ocular radiation risk assessment in populations exposed to environmental radiation contamination >CONDITION OF EYE AND PARAMETERS OF FREE RADICAL PROCESSES IN ORGANISM IN THE LIQUIDATORS AFTER THE CHERNOBYL ACCIDENT
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CONDITION OF EYE AND PARAMETERS OF FREE RADICAL PROCESSES IN ORGANISM IN THE LIQUIDATORS AFTER THE CHERNOBYL ACCIDENT

机译：切尔诺贝利事故后液化器中有机物的眼睛状况和自由基过程的参数

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Eightyfour liquidators from the age of 28 to 58 were examined. The control group consisted of 22 men in the age of 28 to 52 years. A certain increase of infringement of lens transparency without typical attributes of radiation cataract is revealed in the experimental group. Electrophysiological investigation (EPI) shows a certain reduction of amplitude of a-wave of macular electroretinogram (ERG) on green stimulus. Amplitude of flicker-ERG 30 Hz, amplitude of main component and lengthening of interpeak time interval of flicker-ERG 10 Hz are revealed. These changes indicate a tendency of decreasing retinal function in paramacular and in a smaller degree in peripheral zones in liquidators. Contrast sensitivity is definitely reduced in liquidators for achromatic, red, green and blue stimuli on all spatial frequencies. Luminous and color sensitivity to stimuli of different color in liquidators is definitely reduced in all central visual fields, but is highest in the paracentral zone. We investigated 14 parameters for activity of free radical processes and antioxidant system in peripheral blood in both groups. Definite increase of production of the reactive oxygen species and disbalance of a glutathione link of antioxidant protection are revealed. Authentic correlation dependences are revealed: strong direct correlation - between a level of superoxide dismutase and amplitude of the first component of flicker-ERG 10 Hz, moderate direct correlation - between a level of glutathione reductase and amplitude of a main component of flicker-ERG 10 Hz, between a level of reduced glutathione and interpeak time interval of flicker-ERG 10 Hz. In consideration of large spontaneous activity of free radical processes in the normal retina the received results indicate a deterioration.
机译：检查了28至58岁的八十四名清盘人。对照组由22名年龄在28至52岁之间的男性组成。在实验组中，没有透明性白内障的典型特征的情况下，对镜片透明度的侵犯有所增加。电生理研究（EPI）显示，绿色刺激对黄斑视网膜电图（ERG）的a波振幅有一定程度的降低。显示了闪烁ERG 30 Hz的幅度，主要成分的幅度和闪烁ERG 10 Hz的峰间时间间隔的延长。这些变化表明了黄斑旁视网膜的视网膜功能下降的趋势，而在清算人的外围区域中视网膜的功能下降的趋势较小。对于所有空间频率上的消色差，红色，绿色和蓝色刺激，清算器中的对比灵敏度肯定会降低。在所有中央视野中，对清算器中不同颜色的刺激的发光和颜色敏感性肯定会降低，但在中央旁区域最高。我们调查了两组外周血中自由基过程和抗氧化系统活性的14个参数。揭示了活性氧种类的确定增加和抗氧化剂保护的谷胱甘肽连接的失衡。揭示了真实的相关依赖性：强的直接相关性-超氧化物歧化酶水平与闪烁的ERG 10 Hz的第一成分的振幅之间，中等的直接相关性-谷胱甘肽还原酶的水平与闪烁的ERG 10的主要成分的振幅之间的中度直接相关。降低的谷胱甘肽水平与闪烁的ERG的峰间时间间隔之间的10 Hz之间的Hz。考虑到正常视网膜中自由基过程的大量自发活性，收到的结果表明病情恶化。

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