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In-vivo imaging of inner retinal cellular morphology with adaptive optics - optical coherence tomography: challenges and possible solutions

机译：自适应光学技术对视网膜内细胞形态进行体内成像-光学相干断层扫描：挑战和可能的解决方案

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摘要

Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality of in vivo images of cellular structures in the outer layers of the human retina. Despite the significant progress in imaging cone and rod photoreceptor mosaics, visualization of cellular structures in the inner retina has been achieved only with extrinsic contrast agents that have not been approved for use with humans. In this paper we describe the main limiting factors in visualizing inner retinal cells and the methods we implemented to reduce their effects on images acquired with AO-OCT. These include improving the system point spread function (AO performance), monitoring of motion artifacts (retinal motion tracking), and speckle pattern reduction (temporal and spatial averaging). Results of imaging inner retinal morphology and the improvement offered by the new UC Davis AO-OCT system with spatio-temporal image averaging are presented.
机译：视网膜图像采集技术的最新进展，包括光学相干断层扫描（OCT）和扫描激光检眼镜（SLO），并结合了自适应光学（AO）仪器的改进性能，已经改善了体内细胞结构的体内图像质量人体视网膜的外层。尽管在圆锥形和杆状感光体镶嵌成像方面取得了显着进展，但仅使用未经批准可用于人类的外在造影剂，才能实现视网膜内部细胞结构的可视化。在本文中，我们描述了可视化内部视网膜细胞的主要限制因素，以及为减少其对通过AO-OCT采集的图像的影响而实施的方法。这些措施包括改善系统点扩展功能（AO性能），监视运动伪影（视网膜运动跟踪）和减少斑点图案（时间和空间平均）。提出了成像内部视网膜形态的结果以及新的UC Davis AO-OCT系统提供的时空图像平均的改进结果。

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  • 来源
    《Ophthalmic technologies XXII》|2012年|p.82091G.1-82091G.6|共6页
  • 会议地点 San Francisco CA(US)
  • 作者

    Robert J. Zawadzki; Steven M. Jones; Dae Yu Kim; Lisa Poyneer; Arlie G. Capps; Bernd Hamann; Scot S. Olivier; John S. Werner;

  • 作者单位

    Vision Science and Advanced Retinal Imaging Laboratory (VSRI) and Dept. of Ophthalmology Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, CA USA 95817;

    Lawrence Livermore National Laboratory, 6000 East Avenue, Livermore, CA USA 94550;

    Vision Science and Advanced Retinal Imaging Laboratory (VSRI) and Dept. of Ophthalmology Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, CA USA 95817;

    Lawrence Livermore National Laboratory, 6000 East Avenue, Livermore, CA USA 94550;

    Vision Science and Advanced Retinal Imaging Laboratory (VSRI) and Dept. of Ophthalmology Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, CA USA 95817 ,Institute for Data Analysis and Visualization (IDAV), Department of Computer Science, UC Davis,One Shields Avenue, Davis, CA 95616, USA;

    Institute for Data Analysis and Visualization (IDAV), Department of Computer Science, UC Davis,One Shields Avenue, Davis, CA 95616, USA;

    Lawrence Livermore National Laboratory, 6000 East Avenue, Livermore, CA USA 94550;

    Vision Science and Advanced Retinal Imaging Laboratory (VSRI) and Dept. of Ophthalmology Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, CA USA 95817;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 眼科学;
  • 关键词

    adaptive optics; optical coherence tomography; ophthalmology; imaging systems; medical optics instrumentation; aberration compensation; complex conjugate artifact;

    机译：自适应光学光学相干断层扫描；眼科;成像系统；医疗光学仪器；像差补偿；复共轭伪像;

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