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Spatially-resolved Brillouin spectroscopy for in vivo determination of the biomechanical properties of crystalline lenses

机译：空间分辨布里渊光谱用于体内测定晶状体的生物力学性能

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摘要

Confocal Brillouin spectroscopy is an innovative measurement method for the noninvasive determination of rheological tissue properties. Its application in ophthalmology can offer the possibility to determine in vivo the deformation properties of eye lens with spatial resolution. This seems to be a promising approach concerning current presbyopia research. Due to the spatially resolved detection of the viscoelastic lens properties, a better understanding of the natural aging process of the lens and the influences of different lens opacities on the stiffness is expected. Based on spectral data the refractive index profile, the protein concentration and the density profile within the lens tissue can be derived. A measurement set-up for confocal Brillouin microscopy based on spectral analysis of spontaneous Brillouin scattering signals by using a high-resolution dispersive device is presented. First in vivo measurements results on rabbit eyes are presented and evaluated concerning refractive index distribution, protein concentration, density and rheological significance. These data are compared with known research results of ex vivo lenses.
机译：共焦布里渊光谱法是一种创新的测量方法，用于无创测定流变组织特性。它在眼科中的应用可以提供确定体内具有空间分辨率的晶状体变形特性的可能性。对于当前的老花眼研究，这似乎是一种有前途的方法。由于粘弹性镜片特性的空间分辨检测，可以更好地了解镜片的自然老化过程以及不同镜片混浊度对刚度的影响。基于光谱数据，可以得出晶状体组织内的折射率分布，蛋白质浓度和密度分布。提出了一种基于共聚焦布里渊显微镜的测量装置，该系统基于高分辨率分散装置对自发布里渊散射信号进行频谱分析。首先提供兔眼的体内测量结果，并对折射率分布，蛋白质浓度，密度和流变学意义进行评估。将这些数据与离体晶状体的已知研究结果进行比较。

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  • 来源
    《Ophthalmic technologies XXII》|2012年|p.82090T.1-82090T.6|共6页
  • 会议地点 San Francisco CA(US)
  • 作者

    Oliver Stachs; Stephan Reifi; Rudolf Guthoff; Heinrich Stolz;

  • 作者单位

    Faculty of Medicine, Ophthalmology Clinic, University of Rostock, D.1805 5 Rostock, Germany;

    Faculty of Medicine, Ophthalmology Clinic, University of Rostock, D.1805 5 Rostock, Germany ,Institute for Physics, University of Rostock, D.18055 Rostock, Germany;

    Faculty of Medicine, Ophthalmology Clinic, University of Rostock, D.1805 5 Rostock, Germany;

    Faculty of Medicine, Ophthalmology Clinic, University of Rostock, D.1805 5 Rostock, Germany;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 眼科学;
  • 关键词

    brillouin scattering; elastic properties; crystalline lens;

    机译：布里洛因散射弹性晶状体;

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