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Design of a modified endoscope illuminator for spectral imaging of colorectal tissues

机译：用于大肠组织光谱成像的改进型内窥镜照明器的设计

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The gold standard for locating colonic polyps is a white light endoscope in a colonoscopy, however, polyps smaller than 5 mm can be easily missed. Modified procedures such as narrow band imaging have shown only marginal increases in detection rates. Spectral imaging is a potential solution to improve the sensitivity and specificity of colonoscopies by providing the ability to distinguish molecular fluorescence differences in tissues. The goal of this work is to implement a spectral endoscopic light source to acquire spectral image data of colorectal tissues. A beta-version endoscope light source was developed, by retrofitting a white light endoscope light source (Olympus, CLK-4) with 16 narrow band LEDs. This redesigned, beta-prototype uses high-power LEDs with a minimum output of 500 mW to provide sufficient spectral output (0.5 mW) through the endoscope. A mounting apparatus was designed to provide sufficient heat dissipation. Here, we report recent results of our tests to characterize the intensity output through the light source and endoscope to determine the flat spectral output for imaging and intensity losses through the endoscope. We also report preliminary spectral imaging data from transverse pig colon that demonstrates the ability to result in working practical spectral data. Preliminary results of this revised prototype spectral endoscope system demonstrate that there is sufficient power to allow the imaging process to continue and potentially determine spectral differences in cancerous and normal tissue from imaging ex vivo pairs. Future work will focus on building a spectral library for the colorectal region and refining the user interface the system for in vivo use.
机译：用于定位结肠息肉的金标准是结肠镜检查中的白光内窥镜，但是小于5 mm的息肉很容易漏掉。诸如窄带成像之类的修改程序仅显示出检测率的少量增加。光谱成像是一种潜在的解决方案，可通过提供区分组织中分子荧光差异的能力来提高结肠镜检查的敏感性和特异性。这项工作的目的是实现一种光谱内窥镜光源来获取结直肠组织的光谱图像数据。通过使用16个窄带LED改装白光内窥镜光源（奥林巴斯（Olympus），CLK-4），开发了beta版内窥镜光源。经过重新设计的Beta原型使用高功率LED，其最小输出为500 mW，以通过内窥镜提供足够的光谱输出（0.5 mW）。设计安装设备以提供足够的散热。在这里，我们报告了测试的最新结果，以表征通过光源和内窥镜输出的强度，以确定用于成像的平坦光谱输出以及通过内窥镜的强度损失。我们还报告了来自横向猪结肠的初步光谱成像数据，该数据证明了产生实际光谱数据的能力。经修订的原型光谱内窥镜系统的初步结果表明，有足够的能力使成像过程继续进行，并有可能通过离体成像对确定癌组织和正常组织中的光谱差异。未来的工作将集中在为结肠直肠区域建立光谱库，以及完善系统的用户界面以供体内使用。

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