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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XIX >High speed imaging of remotely induced shear waves using phase-sensitive optical coherence tomography
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High speed imaging of remotely induced shear waves using phase-sensitive optical coherence tomography

机译：使用相敏光学相干断层扫描技术对远程感应剪切波进行高速成像

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Shear wave optical coherence elastography (SW-OCE) is a quantitative approach to assess tissue structures and elasticity with high resolution, based on OCT. Shear wave imaging (SWI) is the foundation of shear wave elasticity imaging (SWEI), which is a quantitative approach to assess tissue structures and pathological status. In order to enhance elastography resolution to micron scale, the shear waves needs to be highly localized, with short wavelength and high frequency (second order of kHz), which also places stricter requirement on the temporal resolution requirements of SWI device. In this paper, we introduced two approaches to remotely induce high frequency shear waves within tissue samples: ultrasound acoustic radiation force impulse (ARFI), and high energy nanosecond pulsed laser. The maximum frequency of pulsed laser induced shear waves in tissue-mimicking phantoms can go up to 25 kHz, which is not possible to be captured and tracked by other SWI modalities. We use a custom-built SWI-OCT system to visualize and capture the nanometer scale shear waves, achieving a spatial resolution up to 15 um and frame rate of up to 92 kHz. The dynamic wave propagation data was then used for the reconstruction of localized wave velocity and elasticity. This study demonstrates the non-contact shear wave generation with pulsed laser source, and ultra-fast, high-resolution sectional acoustical wave tracking with remarkable sensitivity, promising a future clinical application for a high-resolution quantitative mapping of elasticity in vivo, non-contact and real time in OCT-accessible tissue, especially in ocular tissues.
机译：剪切波光学相干弹性成像（SW-OCE）是一种基于OCT的定量方法，可以高分辨率评估组织结构和弹性。剪切波成像（SWI）是剪切波弹性成像（SWEI）的基础，它是评估组织结构和病理状态的定量方法。为了将弹性成像分辨率提高到微米级，剪切波需要高度局部化，具有短波长和高频（二阶kHz），这也对SWI设备的时间分辨率要求提出了更严格的要求。在本文中，我们介绍了两种在组织样本中远程感应高频剪切波的方法：超声波辐射力脉冲（ARFI）和高能纳秒脉冲激光。在模仿组织的模型中，脉冲激光诱导的剪切波的最大频率可以高达25 kHz，其他SWI模式无法捕获和跟踪。我们使用定制的SWI-OCT系统来可视化和捕获纳米级剪切波，从而实现高达15 um的空间分辨率和高达92 kHz的帧频。然后将动态波传播数据用于重建局部波速度和弹性。这项研究证明了利用脉冲激光源产生的非接触剪切波，以及具有显着灵敏度的超快速高分辨率断面声波跟踪，有望为高分辨率的体内，非体外弹性定量绘图提供临床应用OCT可及组织（尤其是眼组织）中的接触和实时。

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