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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XIX >High-speed, digitally refocused retinal imaging with Line-field parallel swept source OCT
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High-speed, digitally refocused retinal imaging with Line-field parallel swept source OCT

机译：线性场平行扫频源OCT进行高速数字重新聚焦视网膜成像

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摘要

MHz OCT allows mitigating undesired influence of motion artifacts during retinal assessment, but comes in state-of-the-art point scanning OCT at the price of increased system complexity. By changing the paradigm from scanning to parallel OCT for in vivo retinal imaging the three-dimensional (3D) acquisition time is reduced without a trade-off between speed, sensitivity and technological requirements. Furthermore, the intrinsic phase stability allows for applying digital refocusing methods increasing the in-focus imaging depth range. Line field parallel interferometric imaging (LPSI) is utilizing a commercially available swept source, a single-axis galvo-scanner and a line scan camera for recording 3D data with up to 1MHz A-scan rate. Besides line-focus illumination and parallel detection, we mitigate the necessity for high-speed sensor and laser technology by holographic full-range imaging, which allows for increasing the imaging speed by low sampling of the optical spectrum. High B-scan rates up to 1kHz further allow for implementation of lable-free optical angiography in 3D by calculating the inter B-scan speckle variance. We achieve a detection sensitivity of 93.5 (96.5) dB at an equivalent A-scan rate of 1 (0.6) MHz and present 3D in vivo retinal structural and functional imaging utilizing digital refocusing. Our results demonstrate for the first time competitive imaging sensitivity, resolution and speed with a parallel OCT modality. LPSI is in fact currently the fastest OCT device applied to retinal imaging and operating at a central wavelength window around 800 nm with a detection sensitivity of higher than 93.5 dB.
机译：MHz OCT可以减轻视网膜评估过程中运动伪影的不良影响，但采用最新的点扫描OCT会增加系统复杂性。通过将范式从扫描改为并行OCT以进行体内视网膜成像，可以减少三维（3D）采集时间，而无需在速度，灵敏度和技术要求之间进行权衡。此外，固有相位稳定性允许应用数字重聚焦方法来增加聚焦成像深度范围。线场平行干涉成像（LPSI）正在利用市售的扫频源，单轴振镜扫描器和线扫描相机来以高达1MHz的A扫描速率记录3D数据。除了线聚焦照明和并行检测之外，我们还通过全息全范围成像减轻了高速传感器和激光技术的必要性，从而可以通过光谱的低采样来提高成像速度。高达1kHz的高B扫描速率还可以通过计算B扫描之间的散斑差异来实现无标签的3D光学血管造影术。我们在1（0.6）MHz的等效A扫描速率下实现了93.5（96.5）dB的检测灵敏度，并提出了利用数字重新聚焦的3D体内视网膜结构和功能成像。我们的结果首次证明了具有并行OCT方式的竞争性成像灵敏度，分辨率和速度。实际上，LPSI是目前应用于视网膜成像的最快的OCT设备，并在800 nm左右的中心波长窗口内运行，检测灵敏度高于93.5 dB。

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  • 会议地点 San Francisco CA(US)
  • 作者

    Daniel J. Fechtig; Abhishek Kumar; Laurin Ginner; Wolfgang Drexler; Rainer A. Leitgeb;

  • 作者单位

    Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria,Christian Doppler Laboratory for Laser Development and their Application to Medicine and Biology, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Austria;

    Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria,Christian Doppler Laboratory for Laser Development and their Application to Medicine and Biology, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Austria;

    Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria,Institute of Applied Physics, Technical University Vienna, Wiedner Hauptstrasse 8-10/E134, A-1040 Vienna, Austria;

    Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria,Christian Doppler Laboratory for Laser Development and their Application to Medicine and Biology, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Austria;

    Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria,Christian Doppler Laboratory for Laser Development and their Application to Medicine and Biology, Center for Medical Physics and Biomedical Engineering, Medical University Vienna, Austria;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Optical Coherence Tomography; Retinal Imaging; Line field OCT; Digital Refocusing; Optical Angiography;

    机译：光学相干断层扫描；视网膜成像；线场OCT；数字对焦光学血管造影;

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