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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XIX >Optical microangiography reveals collateral blood perfusion dynamics in mouse cerebral cortex after focal stroke
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Optical microangiography reveals collateral blood perfusion dynamics in mouse cerebral cortex after focal stroke

机译：光学微血管造影显示局灶性卒中后小鼠大脑皮质的侧支血流灌注动态

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摘要

Arteriolo-arteriolar anastomosis's role in regulating blood perfusion through penetrating arterioles during stroke is yet to be discovered. We apply ultra-high sensitive optical microangiography (UHS-OMAG) and Doppler optical microangiography (DOMAG) techniques to evaluate vessel diameter and red blood cell velocity changes in large number of pial and penetrating arterioles in relation with arteriolo-arteriolar anastomosis (AAA) during and after focal stroke. Thanks to the high sensitivity of UHS-OMAG, we were able to image pial microvasculature up to capillary level through a cranial window (9 mm~2), and DOMAG provided clear image of penetrating arterioles up to 500μm depth. Results showed that penetrating arterioles close to a strong AAA connection dilate whereas penetrating arterioles constrict significantly in weaker AAA regions. These results suggest that AAA plays a major role in active regulation of the pial arterioles, and weaker AAA connections lead to poor blood perfusion to penumbra through penetrating arterioles.
机译：小动脉-小动脉吻合在中风过程中通过穿透小动脉调节血液灌注的作用尚未发现。我们应用超高灵敏度光学微血管造影术（UHS-OMAG）和多普勒光学微血管造影术（DOMAG）技术，以评估在动脉粥样硬化-小动脉吻合术（AAA）期间大量的皮层和穿透性小动脉中的血管直径和红细胞速度变化和中风后。由于UHS-OMAG的高灵敏度，我们能够通过颅窗（9 mm〜2）成像直至微血管水平的微血管微血管，而DOMAG可以提供高达500μm深度的穿透小动脉的清晰图像。结果显示，接近强AAA连接的穿透小动脉扩张，而较弱AAA区的穿透小动脉明显收缩。这些结果表明，AAA在主动调节小动脉中起主要作用，而较弱的AAA连接会导致穿透小动脉对半影的血液灌注不良。

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  • 会议地点 San Francisco CA(US)
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    Utku Baran; Yuandong Li; Ruikang K. Wang;

  • 作者单位

    Department of Bioengineering, University of Washington, 3720 15th Ave. NE, Seattle WA 98195, USA,Department of Electrical Engineering, University of Washington, 185 Stevens Way, Seattle WA 98195, USA;

    Department of Bioengineering, University of Washington, 3720 15th Ave. NE, Seattle WA 98195, USA;

    Department of Bioengineering, University of Washington, 3720 15th Ave. NE, Seattle WA 98195, USA;

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