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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XIX >In vivo microvascular imaging of human oral and nasal cavities using swept-source optical coherence tomography with a single forward/side viewing probe
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In vivo microvascular imaging of human oral and nasal cavities using swept-source optical coherence tomography with a single forward/side viewing probe

机译：使用扫描源光学相干层析成像和单个前/侧面观察探针对人口腔和鼻腔进行体内微血管成像

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摘要

We report three-dimensional (3D) imaging of microcirculation within human cavity tissues in vivo using a high-speed swept-source optical coherence tomography (SS-OCT) at 1.3 μm with a modified probe interface. Volumetric structural OCT images of the inner tissues of oral and nasal cavities are acquired with a field of view of 2 mm × 2 mm. Two types of disposable and detachable probe attachments are devised and applied to the port of the imaging probe of OCT system, enabling forward and side imaging scans for selective and easy access to specific cavity tissue sites. Blood perfusion is mapped with OCT-based microangiography from 3D structural OCT images, in which a novel vessel extraction algorithm is used to decouple dynamic light scattering signals, due to moving blood cells, from the background scattering signals due to static tissue elements. Characteristic tissue anatomy and microvessel architectures of various cavity tissue regions of a healthy human volunteer are identified with the 3D OCT images and the corresponding 3D vascular perfusion maps at a level approaching capillary resolution. The initial finding suggests that the proposed method may be engineered into a promising tool for evaluating and monitoring tissue microcirculation and its alteration within a wide-range of cavity tissues in the patients with various pathological conditions.
机译：我们报告了使用改良的探头界面在1.3μm的高速扫频光源光学相干断层扫描（SS-OCT）在体内的人体腔体内微循环的三维（3D）成像。口腔和鼻腔内部组织的体积结构OCT图像以2 mm×2 mm的视野获得。设计了两种类型的一次性和可拆卸探针附件并将其应用于OCT系统的成像探针端口，可进行正向和侧面成像扫描，以便选择性，轻松地访问特定的腔体组织部位。使用基于OCT的微血管造影术从3D结构性OCT图像映射血液灌注，其中使用新颖的血管提取算法将由于运动的血细胞引起的动态光散射信号与由于静态组织元素引起的背景散射信号解耦。用3D OCT图像和相应的3D血管灌注图以接近毛细血管分辨率的水平来识别健康人类志愿者的各个腔组织区域的特征组织解剖结构和微血管结构。最初的发现表明，可以将所提出的方法设计成一种有前途的工具，用于评估和监测具有各种病理状况的患者在广泛的腔组织中的组织微循环及其改变。

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