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Advances in a fully integrated intravascular OCT-Ultrasound system for cardiovascular imaging

机译:用于心血管成像的完全集成的血管内OCT-超声系统的研究进展

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摘要

Intracoronary optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are two popular techniques for the detection and determination of atherosclerosis. IVUS allows visualization of plaques while also providing a large penetration depth to determine plaque volume. Intracoronary OCT provides the ability to capture microscopic features associated with high risk plaque. Traditionally to utilize the benefits of both modalities, separate probes and systems had to be used one at a time to image a vessel. We present work required to create a combined OCT IVUS system capable of simultaneous imaging to detect atherosclerotic plaques. A novel integrated probe of size 0.69 mm OD featuring sequential placement of components was created to acquire co-registered images within small coronary vessels. By utilizing commercial graphics processing units (GPUs) real time visualization of acquired data is possible up to a maximum 48 frames per second per channel. In vitro studies on human coronary artery samples as well as in vivo studies in rabbits and pigs show various plaque buildups in both OCT and IVUS images which match histology results, demonstrating the capabilities of the system.
机译:冠状动脉内光学相干断层扫描(OCT)和血管内超声(IVUS)是检测和确定动脉粥样硬化的两种流行技术。 IVUS可以可视化斑块,同时还可以提供较大的穿透深度来确定斑块体积。冠状动脉内OCT能够捕获与高风险斑块相关的微观特征。传统上,为了利用两种方式的优势,必须一次使用单独的探头和系统来对血管成像。我们介绍创建能够同时成像以检测动脉粥样硬化斑块的组合式OCT IVUS系统所需的工作。创建了外径为0.69 mm的新型集成探头,该探头具有顺序放置组件的功能,以获取小冠状动脉内的共同配准图像。通过利用商用图形处理单元(GPU),可以实时可视化获取的数据,每通道每秒最多48帧。对人冠状动脉样品的体外研究以及对兔和猪的体内研究表明,OCT和IVUS图像中都有各种噬菌斑堆积,这与组织学结果相符,证明了该系统的功能。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者单位

    University of California, Irvine, Dept. of Biomedical Engineering, Irvine, California 92697;

    University of California, Irvine, Dept. of Biomedical Engineering, Irvine, California 92697;

    University of Southern California, NIH Ultrasonic Transducer Resource Center and Department of Biomedical Engineering, Los Angeles, California 90089;

    University of California, Irvine, Dept. of Biomedical Engineering, Irvine, California 92697;

    Beckman Laser Institute and the Center for Biomedical Imaging, UCIrvine, CA 92612;

    University of California, Irvine, Division of Cardiology, Medical Center, Orange, California 92868;

    University of California, Irvine, Division of Cardiology, Medical Center, Orange, California 92868;

    University of Southern California, NIH Ultrasonic Transducer Resource Center and Department of Biomedical Engineering, Los Angeles, California 90089;

    University of California, Irvine, Dept. of Biomedical Engineering, Irvine, California 92697,Beckman Laser Institute and the Center for Biomedical Imaging, UCIrvine, CA 92612;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
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