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Quantitative optical coherence tomography by maximum a-posteriori estimation of signal intensity

机译：通过最大后验估计信号强度进行定量光学相干断层扫描

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摘要

A maximum a-posteriori (MAP) estimator for signal amplitude of optical coherence tomography (OCT) is presented. This estimator provides an accurate and low bias estimation of the correct OCT signal amplitude even at very low signal-to-noise ratios. As a result, contrast improvement of retinal OCT images is demonstrated. In addition, this estimation method allows for an estimation reliability to be calculated. By combining the MAP estimator with a previously demonstrated attenuation imaging algorithm, we present attenuation coefficient images of the retina. From the reliability derived from the MAP image one can also determine which regions of the attenuation images are unreliable. From Jones matrix OCT data of the optic nerve head (ONH), we also demonstrate that combining MAP with polarization diversity (PD) OCT images can generate intensity images with fewer birefringence artifacts, resulting in better attenuation images. Analysis of the MAP intensity images shows higher image SNR than averaging.
机译：提出了光学相干断层扫描（OCT）信号幅度的最大后验（MAP）估计器。即使在非常低的信噪比下，该估计器也可以对正确的OCT信号幅度提供准确且低偏差的估计。结果，证明了视网膜OCT图像的对比度提高。另外，该估计方法允许计算估计可靠性。通过将MAP估计器与先前演示的衰减成像算法结合起来，我们呈现了视网膜的衰减系数图像。根据从MAP图像得出的可靠性，还可以确定衰减图像的哪些区域不可靠。从视神经乳头（ONH）的Jones矩阵OCT数据中，我们还证明了将MAP与偏振分集（PD）OCT图像结合可以生成强度图像，该图像具有较少的双折射伪像，从而产生更好的衰减图像。对MAP强度图像的分析显示，图像SNR高于平均水平。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Aaron C. Chan; Kazuhiro Kurokawa; Shuichi Makita; Young-Joo Hong; Arata Miyazawa; Masahiro Miura; Yoshiaki Yasuno;

  • 作者单位

    Computational Optics Group, University of Tsukuba, Japan,Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan;

    Computational Optics Group, University of Tsukuba, Japan,Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan;

    Computational Optics Group, University of Tsukuba, Japan,Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan;

    Computational Optics Group, University of Tsukuba, Japan,Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan;

    Computational Optics Group, University of Tsukuba, Japan,Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan;

    Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan,Department of Ophthalmology, Tokyo Medical University Ibaraki Medical Center;

    Computational Optics Group, University of Tsukuba, Japan,Computational Optics and Ophthalmology Group, Tsukuba, Ibaraki, Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    OCT; maximum a-posteriori estimator; attenuation coefficient; retinal imaging; birefringence;

    机译：华侨城;最大后验估计量;衰减系数视网膜成像双折射;

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