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THE HOW AND WHY OF A $10 OPTICAL COHERENCE TOMOGRAPHY SYSTEM

机译:$ 10光学相干断层扫描系统的方式和原因

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摘要

Optical Coherence Tomography (OCT) is the fastest growing medical imaging modality with more than $1Bln worth of scans ordered and over $400M worth of equipment shipped in 2010, just nine years after its commercialization. It is at various stages of acceptance and approval for eye care, coronary care and skin cancer care and is spreading rapidly to other medical specialties. Indeed, it is the leading success of translation of biophotonics science into clinical practice. Significant effort is being made to provide sufficient evidence for efficacy across a broad range of applications, but more needs to be done to radically reduce the cost of OCT so that it can spread to underserved markets and address new, fast growing opportunities in mobile health monitoring. Currently, a clinical OCT system ranges in price from ~$50k to ~$150k, typically is housed on a bedside trolley, runs off AC power, and requires skilled, extensively trained technicians to operate. The cost, size, and skill level required keep this wonderful technology beyond the reach of mainstream primary care, much less individual consumers seeking to monitor their health on a routine basis outside of typical clinical settings and major urban medical centers. Beyond the first world market, there are 6.5 billion people with similar eye and skin cancer care needs which cannot be met by the current generation of large, expensive, complex, and delicate OCT systems. This paper will describe a means to manufacture a low cost, compact, simple, and robust OCT system, using parts and a configuration similar to a CD-ROM or DVD pickup unit (see figure 1). Essentially, this system-multiple reference OCT (MR-OCT)-is based on the use of a partial mirror in the reference arm of a time domain OCT system to provide multiple references, and hence A-scans, at several depths simultaneously (see figure 2). We have already shown that a system based on this configuration can achieve an SNR of greater than 90 dB, which is sufficient for many medical imaging and biometry applications.
机译:光学相干断层扫描(OCT)是增长最快的医学成像设备,在其商业化仅九年后的2010年,订购了价值超过10亿美元的扫描仪和价值超过4亿美元的设备。它处于眼部护理,冠状动脉护理和皮肤癌护理的接受和批准的各个阶段,并且正迅速传播到其他医学专业。的确,这是将生物光子学转化为临床实践的主要成功。正在做出巨大的努力以提供足够的证据来证明其在各种应用中的功效,但还需要做更多的工作以从根本上降低OCT的成本,以便将其推广到服务不足的市场并应对移动健康监测中新的,快速增长的机会。目前,临床OCT系统的价格从50,000美元到50,000美元不等,通常安装在床头手推车上,使用交流电源,并且需要熟练,训练有素的技术人员来操作。所需的成本,规模和技能水平使这项出色的技术超出了主流初级保健的范围,而寻求在常规临床环境和主要城市医疗中心以外进行日常健康监测的个人消费者则要少得多。除了第一世界市场,还有65亿人具有类似的眼部和皮肤癌护理需求,而当前的大型,昂贵,复杂和精致的OCT系统无法满足这些需求。本文将介绍一种使用类似于CD-ROM或DVD拾取单元的部件和配置来制造低成本,紧凑,简单且耐用的OCT系统的方法(见图1)。本质上,此系统-多参考OCT(MR-OCT)-基于在时域OCT系统的参考臂中使用部分反射镜,以同时在多个深度提供多个参考,从而提供A扫描(请参见图2)。我们已经表明,基于此配置的系统可以实现大于90 dB的SNR,对于许多医学成像和生物统计应用来说已经足够。

著录项

  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者单位

    Tissue Optics and Microcirculation Imaging Group, School of Physics, National University of Ireland Galway, Galway, Ireland,National Biophotonics and Imaging Platform, Ireland;

    Compact Imaging, Inc., 897 Independence Ave., Suite 5B, Mountain View, CA 94043 USA;

    Compact Imaging, Inc., 897 Independence Ave., Suite 5B, Mountain View, CA 94043 USA;

    Science Foundation Ireland/Irish Photonic Integration Centre (IPIC), Tyndall National Institute, Cork, Ireland;

    Tissue Optics and Microcirculation Imaging Group, School of Physics, National University of Ireland Galway, Galway, Ireland;

    Tissue Optics and Microcirculation Imaging Group, School of Physics, National University of Ireland Galway, Galway, Ireland;

    Compact Imaging, Inc., 897 Independence Ave., Suite 5B, Mountain View, CA 94043 USA;

    Tissue Optics and Microcirculation Imaging Group, School of Physics, National University of Ireland Galway, Galway, Ireland,National Biophotonics and Imaging Platform, Ireland;

    Science Foundation Ireland/Irish Photonic Integration Centre (IPIC), Tyndall National Institute, Cork, Ireland;

    Tissue Optics and Microcirculation Imaging Group, School of Physics, National University of Ireland Galway, Galway, Ireland,Compact Imaging, Inc., 897 Independence Ave., Suite 5B, Mountain View, CA 94043 USA;

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