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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XX >Corneal elastic anisotropy and hysteresis as a function of IOP assessed by optical coherence elastography
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Corneal elastic anisotropy and hysteresis as a function of IOP assessed by optical coherence elastography

机译：光学相干弹性成像技术评估角膜弹性各向异性和滞后与眼压的关系

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摘要

The mechanical anisotropic properties of the cornea can be an important indicator for determining the onset and severity of different diseases and can be used to assess the efficacy of various therapeutic interventions, such as cross-linking and LASDC surgery. In this work, we introduce a noncontact method of assessing corneal mechanical anisotropy as a function of intraocular pressure (IOP) using optical coherence elastography (OCE). A focused air-pulse induced low amplitude (＜10 μm) elastic waves in fresh porcine corneas in the whole eye-globe configuration in situ. A phase-stabilized swept source optical coherence elastography (PhS-SSOCE) system imaged the elastic wave propagation at stepped radial angles, and the OCE measurements were repeated as the IOP was cycled. The elastic wave velocity was then quantified to determine the mechanical anisotropy and hysteresis of the cornea. The results show that the elastic anisotropy at the corneal of the apex of the cornea becomes more pronounced at higher IOPs, and that there are distinct radial angles of higher and lower stiffness. Due to the noncontact nature and small amplitude of the elastic wave, this method may be useful for characterizing the elastic anisotropy of ocular and other tissues in vivo completely noninvasively.
机译：角膜的机械各向异性是确定不同疾病发作和严重程度的重要指标，可用于评估各种治疗性干预措施（例如交联和LASDC手术）的功效。在这项工作中，我们介绍了一种使用光学相干弹性成像（OCE）评估作为眼内压（IOP）函数的角膜机械各向异性的非接触方法。聚焦的空气脉冲在整个猪眼球结构中在新鲜猪角膜中引起低振幅（＜10μm）的弹性波。相稳定的扫频源光学相干弹性成像（PhS-SSOCE）系统对弹性波在阶梯状径向角处的传播进行成像，并在IOP循环时重复进行OCE测量。然后，对弹性波速度进行定量，以确定角膜的机械各向异性和磁滞。结果表明，在较高的眼内压下，角膜根尖角膜的弹性各向异性变得更加明显，并且存在较高和较低刚度的不同径向角。由于弹性波的非接触性质和小振幅，此方法可用于完全无创地表征体内眼和其他组织的弹性各向异性。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Jiasong Li; Manmohan Singh; Zhaolong Han; Chen Wu; Raksha Raghunathan; Chih-Hao Liu; Achuth Nair; Shezaan Noorani; Salavat R Aglyamov; Michael D. Twa; Kirill V. Larin;

  • 作者单位

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX;

    Department of Biomedical Engineering, University of Texas at Austin, 107 W Dean Keeton Street, Austin, TX;

    School of Optometry, University of Alabama at Birmingham, 1716 University Blvd. Birmingham, AL;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX,Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk, Russia,Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Optical coherence tomography; optical coherence elastography; elasticity; Young's modulus; anisotropy; intraocular pressure; hysteresis; cornea;

    机译：光学相干断层扫描；光学相干弹性成像弹性;杨氏模量各向异性眼压;磁滞角膜;

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