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Optical Coherence Tomography for blood glucose monitoring through signal attenuation

机译：光学相干断层扫描通过信号衰减监测血糖

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Development of non-invasive techniques for glucose monitoring is crucial to improve glucose control and treatment adherence in patients with diabetes. Hereafter, Optical Coherence Tomography (OCT) may offer a good alternative for portable glucometers, since it uses light to probe samples. Changes in the object of interest can alter the intensity of light returning from the sample and, through it, one can estimate the sample's attenuation coefficient (μ_t) of light. In this work, we aimed to explore the behavior of μ_t of mouse's blood under increasing glucose concentrations. Different samples were prepared in four glucose concentrations using a mixture of heparinized blood, phosphate buffer saline and glucose. Blood glucose concentrations were measured with a blood glucometer, for reference. We have also prepared other samples diluting the blood in isotonic saline solution to check the effect of a higher multiple-scattering component on the ability of the technique to differentiate glucose levels based on μ_t. The OCT system used was a commercial Spectral Radar OCT with 930 nm central wavelength and spectral bandwidth (FWHM) of 100 nm. The system proved to be sensitive for all blood glucose concentrations tested, with good correlations with the obtained attenuation coefficients. A linear tendency was observed, with an increase in attenuation with higher values of glucose. Statistical difference was observed between all groups (p＜0.001). This work opens the possibility towards a non-invasive diagnostic modality using OCT for glycemic control, which eliminates the use of analytes and/or test strips, as in the case with commercially available glucometers.
机译：开发无创葡萄糖监测技术对于改善糖尿病患者的血糖控制和治疗依从性至关重要。此后，光学相干断层扫描（OCT）可以为便携式血糖仪提供一个很好的选择，因为它使用光来探测样品。感兴趣对象的变化可以改变从样本返回的光的强度，并且通过它可以估计样本的光衰减系数（μ_t）。在这项工作中，我们旨在探索在葡萄糖浓度增加的情况下小鼠血液μ_t的行为。使用肝素化血液，磷酸盐缓冲液和葡萄糖的混合物以四种葡萄糖浓度制备不同的样品。作为参考，用血糖仪测量血糖浓度。我们还准备了其他样品在等渗盐水溶液中稀释血液，以检查更高的多重散射成分对基于μt区分葡萄糖水平的技术的影响。所使用的OCT系统是商用光谱雷达OCT，其中心波长为930 nm，光谱带宽（FWHM）为100 nm。该系统对所有测试的血糖浓度均敏感，并且与获得的衰减系数具有良好的相关性。观察到线性趋势，随着较高的葡萄糖值衰减增加。各组间差异有统计学意义（p ＜0.001）。这项工作为使用OCT进行血糖控制提供了一种非侵入性的诊断方式，从而消除了使用分析物和/或试纸的可能性，就像在商用血糖仪中一样。

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