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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XXI >Compact LED-based full-field optical coherence microscopy for high-resolution high-speed in vivo imaging
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Compact LED-based full-field optical coherence microscopy for high-resolution high-speed in vivo imaging

机译：基于紧凑型LED的全场光学相干显微镜，用于高分辨率高速体内成像

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摘要

This work reports on a compact full-field optical coherence microscopy (FF-OCM) setup specifically designed to meet the needs for in vivo imaging, illuminated by a high-brightness broadband light emitting diode (LED). Broadband LEDs have spectra potentially large enough to provide imaging spatial resolutions similar to those reached using conventional halogen lamps, but their radiance can be much higher, which leads to high speed acquisition and makes in vivo imaging possible. We introduce a FF-OCM setup using a 2.3 W broadband LED, with an interferometer designed to be as compact as possible in order to provide the basis for a portable system that will make it possible to fully benefit from the capacity for in vivo imaging by providing the ability to image any region of interest in real-time. The interferometer part of the compact FF-OCM setup weighs 210 g for a size of 11×11×5 cm~3. Using this setup, a sub-micron axial resolution was reached, with a detection sensitivity of 68 dB at an imaging rate of 250 Hz. Due to the high imaging rate, the sensitivity could be improved by accumulation while maintaining an acquisition time short enough for in vivo imaging. It was possible to reach a sensitivity of 75 dB at a 50 Hz imaging rate. High resolution in vivo human skin images were obtained with this setup and compared with images of excised human skin, showing high similarity.
机译：这项工作报告了一种紧凑型全场光学相干显微镜（FF-OCM）装置，该装置专门设计用于满足体内成像的需求，并通过高亮度宽带发光二极管（LED）进行照明。宽带LED的光谱可能足够大，可以提供与使用传统卤素灯所达到的相似的成像空间分辨率，但是它们的辐射度可能更高，这导致了高速采集并使得体内成像成为可能。我们介绍了一种使用2.3 W宽带LED的FF-OCM装置，其干涉仪设计得尽可能紧凑，以便为便携式系统提供基础，从而使该系统可以充分受益于以下方面的体内成像能力：提供实时成像任何感兴趣区域的能力。紧凑型FF-OCM装置的干涉仪部分重量为210 g，尺寸为11×11×5 cm〜3。使用此设置，可以达到亚微米的轴向分辨率，在250 Hz的成像速率下的检测灵敏度为68 dB。由于高成像速率，可以通过积累提高灵敏度，同时保持足够短的采集时间以进行体内成像。在50 Hz的成像速率下，有可能达到75 dB的灵敏度。通过这种设置可获得高分辨率的体内人类皮肤图像，并将其与切除的人类皮肤图像进行比较，显示出高度相似性。

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