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首页> 外文会议>Optical Coherence Tomography and Coherence Techniques III; Progress in Biomedical Optics and Imaging; vol.8 no.40; Proceedings of SPIE-The International Society for Optical Engineering; vol.6627 >In vivo and 3D Visualization of Coronary Artery Development by Optical Coherence Tomography
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In vivo and 3D Visualization of Coronary Artery Development by Optical Coherence Tomography

机译：光学相干断层扫描在体内和3D可视化冠状动脉发育

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摘要

One of the most critical but poorly understood processes during cardiovascular development is the establishment of a functioning coronary artery (CA) system. Due to the lack of suitable imaging technologies, it is currently impossible to visualize this complex dynamic process on living human embryos. Furthermore, due to methodological limitations, this intriguing process has not been unveiled in living animal embryos, too. We present here, to the best of our knowledge, the first in vivo images of developing Cas obtained from the hearts of chick embryos grown in shell-less cultures. The in vivo images were generated by optical coherence tomography (OCT). The OCT system used in this study is a mobile fiber-based time-domain real-time OCT system operating with a center wavelength of 1330 nm, an A-scan rate of 4 kHz, and a typical frame rate of 8 frames/s. The axial resolution is 17 μm (in tissue), and the lateral resolution is 30 μm. The OCT system is optimized for in vivo chick heart visualization and enables OCT movie recording with 8 frames/s, full-automatic 3D OCT scanning, and blood flow visualization, I.e., Doppler OCT imaging. Using this OCT system, we generated in vivo OCT recordings of chick embryo hearts to study the process of connection of the future right coronary artery (RCA) to the aorta. Recordings were made at three critical stages during development: day 8 (no clear connection yet), day 9 (established connection of RCA with the aorta with clear blood flow) and day 10 (further remodeling of the established RCA).
机译：心血管发育过程中最关键但了解最少的过程之一是功能性冠状动脉（CA）系统的建立。由于缺乏合适的成像技术，目前无法在活的人类胚胎上可视化这种复杂的动态过程。此外，由于方法上的限制，这种有趣的过程也没有在活体动物胚胎中揭示出来。据我们所知，我们在这里展示了从无壳培养物中生长的雏鸡心脏获得的Cas发育中的第一张体内图像。体内图像是通过光学相干断层扫描（OCT）生成的。本研究中使用的OCT系统是基于移动光纤的时域实时OCT系统，其中心波长为1330 nm，A扫描速率为4 kHz，典型帧速率为8帧/秒。轴向分辨率为17μm（组织内），横向分辨率为30μm。 OCT系统针对体内鸡心脏可视化进行了优化，并能够以8帧/秒的速度记录OCT电影，全自动3D OCT扫描和血流可视化（即多普勒OCT成像）。使用此OCT系统，我们生成了鸡胚心脏的体内OCT记录，以研究未来右冠状动脉（RCA）与主动脉的连接过程。在发育过程的三个关键阶段进行了记录：第8天（尚无明确的联系），第9天（RCA与主动脉建立的联系且血液流动清晰）和第10天（已建立的RCA的进一步重塑）。

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