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Data correction method based on the floating reference point for the noninvasive glucose sensing

机译：基于浮动参考点的无创葡萄糖感测数据校正方法

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摘要

As an effective noninvasive method for glucose doesn't come into clinical realization due to the weakness of glucose unique signal and complexity of background noise, a method based on a floating reference point and a measuring point, where the diffuse reflectance intensity is insensitive and most sensitive to the variation of glucose concentration, respectively, is applied. In this paper, the data processing method based on the information of reference point was investigated to improve the precision of glucose sensing. The diffuse reflectance of intralipid solution with different glucose concentration in different source-detector distances was obtained by Monte-Carlo simulation. And the radial region selection of reference position and measuring position were discussed. Then in order to simulate the actual measurement condition, the random noise and linear drift were added on the simulated spectra. And the spectra in the proper measuring region corrected by that in the reference point were used to build the multivariate model. Further more, the corresponding optical probe was designed according to the distribution of light intensity in the radial distance and an in vitro experiment about intralipid solution with different glucose concentration was conducted to verify the effect of the data correction based on the information from the reference point. Results showed that, three different measuring regions should be determined in the wavelength of 1100nm-1700nm according to the wavelength characteristic of reference point. And the measuring region should be about 0.2-0.3mm far away from the reference region. For the simulation and in vitro experiment, after the correction by the information from the reference point, the prediction error for glucose was reduced by 46.2% and 23.2%, respectively.
机译：由于葡萄糖独特信号的弱点和背景噪声的复杂性，作为一种有效的非侵入性葡萄糖治疗方法尚未在临床上实现，因此该方法是基于浮动参考点和测量点的，其漫反射强度不敏感，且大多数分别对葡萄糖浓度的变化敏感。本文研究了基于参考点信息的数据处理方法，以提高葡萄糖感测的精度。通过蒙特卡洛模拟，获得了不同浓度的葡萄糖在不同的源-检测器距离内的脂质溶液的漫反射率。讨论了参考位置和测量位置的径向区域选择。然后，为了模拟实际的测量条件，在模拟频谱上添加了随机噪声和线性漂移。并利用参考点校正后的适当测量区域内的光谱建立多元模型。此外，根据光强度在径向距离上的分布设计相应的光学探头，并针对不同葡萄糖浓度的脂质体内溶液进行了体外实验，以基于参考点的信息验证数据校正的效果。 。结果表明，应根据参考点的波长特性，在1100nm-1700nm的波长范围内确定三个不同的测量区域。并且测量区域应远离参考区域约0.2-0.3mm。对于模拟和体外实验，通过参考点的信息进行校正后，葡萄糖的预测误差分别降低了46.2％和23.2％。

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  • 来源
    《Optical diagnostics and sensing IX》|2009年|71860O.1-71860O.9|共9页
  • 会议地点 San Jose CA(US)
  • 作者

    Rong Liu; Bin He; Kexin Xu; Yue Yang;

  • 作者单位

    State key laboratory of precision measuring technology and instruments, Tianjin University, Tianjin 300072, P. R. China;

    State key laboratory of precision measuring technology and instruments, Tianjin University, Tianjin 300072, P. R. China;

    State key laboratory of precision measuring technology and instruments, Tianjin University, Tianjin 300072, P. R. China;

    State key laboratory of precision measuring technology and instruments, Tianjin University, Tianjin 300072, P. R. China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    glucose; reference point; measuring point; non-invasive;

    机译：葡萄糖;参照点;测量点非侵入性;

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