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Ultra high phase sensitive surface plasmon resonance biosensor

机译:超高相敏表面等离子体共振生物传感器

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摘要

This study demonstrates a novel phase-sensitive surface plasman resonance biosensor (PS-SPRB) which is able to convert the phase modulation into amplitude modulation analytically via a differential amplifier. PS-SPRB is able to measure biomolecule interactions at ultra-low concentration relying on the properties of phase sensitive detection at shot-noise detection in a real-time. The common-phase noise-rejection mode is provided in PS-SPRB to be able to immune the background phase noise efficiently. The experimental results confirm the detection sensitivity of 0.00001 wt % concentration of sucrose solution and 10 fg/ml mouse igG interaction with anti IgG in real time.
机译:这项研究演示了一种新型的相敏表面等离子体共振生物传感器(PS-SPRB),该传感器能够通过差分放大器将相位调制转换为幅度调制。 PS-SPRB能够根据散粒噪声检测中的相敏检测特性实时测量超低浓度下的生物分子相互作用。 PS-SPRB中提供了共相噪声抑制模式,可以有效地消除背景相位噪声。实验结果证实了浓度为0.00001 wt%的蔗糖溶液的检测灵敏度以及10 fg / ml小鼠igG与抗IgG的实时相互作用。

著录项

  • 来源
    《Optical diagnostics and sensing IX》|2009年|71860I.1-71860I.7|共7页
  • 会议地点 San Jose CA(US)
  • 作者

    Ying-Chang Li; Chien Chou;

  • 作者单位

    Department of Optics and Photonics, National Central University, Jhongli 320, Taiwan;

    Department of Optics and Photonics, National Central University, Jhongli 320, Taiwan Institute of Biophotonics, National Yang-Ming University, Taipei 112, Taiwan Department of Biomedical Imaging and Radiological Science, National Yang-Ming University, Taipei 112, Taiwan Graduate Institute of Electro-Optical Engineering, Chang Gung University, Taoyuan 333, Taiwan;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    surface plasmon resonance (SPR); Surface plasmon wave (SPW); phase sensitive; biosensor; biomolecular interaction; heterodyne;

    机译:表面等离子体共振(SPR);表面等离激元波(SPW);相位敏感生物传感器生物分子相互作用外差;

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