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Real-time Dual Wavelength Polarimetry for Glucose Sensing

机译：实时双波长极化法用于葡萄糖传感

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Proper treatment of diabetes includes maintenance of near normal blood glucose levels, which can only be achieved with frequent blood glucose monitoring. Current blood finger-stick methods for glucose sensing are invasive, often resulting in low patient compliance and poor disease control. The development of a noninvasive glucose sensor has the potential to provide optimal management of diabetes. Our proposed noninvasive approach is based on an optical polarimetry system for probing the anterior chamber of the eye. The sensor would eventually be used to measure the aqueous humor glucose concentration as a means to determine the blood glucose concentration. In this report, we present the development of a near real-time (less than 1 second) dual wavelength closed-loop polarimetric system to minimize glucose prediction error in the presence of varying birefringence due to motion artifact. The new dual wavelength polarimetric system and in vitro glucose measurement results will be presented which demonstrate the sensitivity and accuracy of the system in the presence of varying birefringence.
机译：糖尿病的正确治疗包括维持接近正常的血糖水平，这只能通过频繁监测血糖来实现。当前用于葡萄糖感测的血液指棒方法是侵入性的，经常导致患者依从性低和疾病控制差。非侵入性葡萄糖传感器的发展具有提供最佳糖尿病管理的潜力。我们提出的非侵入性方法基于用于探测眼前房的光学偏振仪系统。该传感器最终将用于测量房水葡萄糖浓度，作为确定血糖浓度的手段。在此报告中，我们介绍了近实时（不到1秒）双波长闭环极化系统的开发，以在由于运动伪影而引起的双折射变化的情况下，将葡萄糖预测误差降至最低。将介绍新的双波长极化系统和体外葡萄糖测量结果，这些结果证明了在存在不同双折射的情况下系统的灵敏度和准确性。

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