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Flow of blood-saline mixtures studied by time-domain optical coherence tomography

机译：时域光学相干断层扫描研究血盐混合物的流动

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In-vitro analysis of flowing blood-saline mixtures is performed by time-domain optical coherence tomography imaging. The mixtures contain blood in concentrations ranging from 100% to 20%. For each image, a corresponding compounded profile is obtained by adding one thousand adjacent A-scans. The compounded profiles are used for characterizing the optical coherence tomography signal as it propagates within the studied blood-saline mixtures. The results obtained point toward the possibility of acquiring intra-vascular images of arterial tissue that is located behind slabs of flowing blood-saline. A threshold in the propagation distance beyond which the recorded signal becomes dominated by its multiple scattered components is established along the compounded profiles. The threshold location, at a depth of～0.6 mm, is independent of blood concentration. Further investigation of the compounded profiles reveals that the region extending to a maximum depth of about 200 μm from the point where the probing beam enters blood-saline mixtures could reveal information about the flow regime. This opens the possibility of another application for time-domain optical coherence tomography in intravascular imaging: assessing the flow regime, i.e. laminar or turbulent.
机译：通过时域光学相干断层扫描成像对流动的血盐混合物进行体外分析。混合物中所含血液的浓度范围为100％至20％。对于每个图像，通过添加一千个相邻的A扫描获得相应的复合轮廓。复合轮廓用于表征光学相干断层扫描信号，因为它在研究的血盐混合物中传播。所获得的结果表明，有可能获取位于流动的生理盐水平板后面的动脉组织的血管内图像。沿着复合曲线建立传播距离的阈值，超过该阈值时，已记录的信号将由其多个散射分量决定。阈值位置约为0.6 mm，与血液浓度无关。对复合轮廓的进一步研究表明，从探测光束进入血盐混合物的位置延伸到最大深度约200μm的区域可能会揭示有关流动状态的信息。这为血管内成像中时域光学相干断层扫描的另一种应用打开了可能性：评估流动状态，即层流或湍流。

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