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首页> 外文会议>Optical diagnostics and sensing XIV: toward point-of-care diagnostics >Influence of spectral bandwidth limitations of tuneable external-cavity based quantum cascade laser systems for clinical biofluid analysis
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Influence of spectral bandwidth limitations of tuneable external-cavity based quantum cascade laser systems for clinical biofluid analysis

机译：基于可调谐外腔的量子级联激光系统的光谱带宽限制对临床生物流体分析的影响

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In many publications, infrared spectroscopy excelled in multi-analyte assays of biofluids. Based on such technology, laboratory and point-of-care applications can be envisaged and most needed devices are for blood glucose measurements. Implementing strict glycemic control can reduce the risk of serious complications in both diabetic and critically ill patients. For this purpose, many different blood glucose monitoring techniques and insulin infusion strategies have been tested towards the realization of an artificial pancreas under closed loop control. However, for patient portable instrumentation current FTIR-spectrometers are still too bulky, which need replacement by devices that allow further miniaturization. Recently developed external cavity quantum cascade lasers (EC-QCL) are tuneable over about 200 cm~(-1), which however is still narrow, compared to the range accessible with FTIR-devices. In this work, we applied bandwidth constraints to previous FTIR-studies on blood plasma and dialysates of biofluids. For the clinically most important blood glucose no impairment was found using one laser only, provided that specific interferents were missing. Other analytes of interest, such as lactate and urea, indicated the need of broader tuneability over about 500 cm~(-1) with a second or third laser for a simultaneous glucose assay.
机译：在许多出版物中，红外光谱在生物流体的多分析物测定中均表现出色。基于这样的技术，可以设想实验室和即时护理应用，并且最需要的设备用于血糖测量。实施严格的血糖控制可以降低糖尿病和重症患者严重并发症的风险。为了这个目的，已经测试了许多不同的血糖监测技术和胰岛素输注策略，以在闭环控制下实现人造胰腺。但是，对于患者便携式仪器而言，当前的FTIR光谱仪仍然过于庞大，需要替换为能够进一步小型化的设备。最近开发的外腔量子级联激光器（EC-QCL）可以在200 cm〜（-1）的范围内进行调谐，但是与FTIR器件可访问的范围相比，它仍然很窄。在这项工作中，我们将带宽限制应用于先前的关于血浆和生物流体透析液的FTIR研究。对于临床上最重要的血糖，如果缺少特定的干扰物，则仅使用一台激光就不会发现损害。其他感兴趣的分析物，例如乳酸盐和尿素，表明需要使用第二或第三激光同时进行葡萄糖测定，需要在约500 cm-1（-1）范围内具有更宽的可调谐性。

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