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Noncontact Depth-Resolved Micro-Scale Corneal Elastography

机译：非接触深度分辨的微型角膜弹性成像

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摘要

Noninvasive high-resolution depth-resolved measurement of corneal biomechanics is of great clinical significance for improving the diagnosis and optimizing the treatment of various degenerated ocular diseases. Here, we report a micro-scale optical coherence elastography (OCE) method that enables noncontact assessment of the depthwise elasticity distribution in the cornea. The OCE system combines a focused air-puff device with phase-sensitive optical coherence tomography (OCT). Low-pressure short-duration air stream is used to load the cornea with the localized displacement at micron level. The phase-resolved OCT detection with nano-scale sensitivity probes the induced corneal deformation at various locations within a scanning line, providing the ultra-fast imaging of the corneal lamb wave propagation. With spectral analysis, the amplitude spectra and the phase spectra are available for the estimation of the frequency range of the lamb wave and the quantification of the wave propagation, respectively. Curved propagation paths following the top and bottom corneal boundaries are selected inside the cornea for measuring the phase velocity of the lamb wave at the major frequency components over the whole depths. Our pilot experiments on ex vivo rabbit eyes indicate the distinct stiffness of different layers in the cornea, including the epithelium, the anterior stroma, the posterior stroma, and the innermost region, which demonstrates the feasibility of this micro-scale OCE method for noncontact depth-resolved corneal elastography. Also, the quantification of the lamb wave dispersion in the cornea could lead to the measurement of the elastic modulus, suggesting the potential of this method for quantitative monitoring of the corneal biomechanics.
机译：角膜生物力学的无创高分辨率深度分辨测量对于改善各种退化性眼病的诊断和优化治疗具有重要的临床意义。在这里，我们报告了一种微型光学相干弹性成像（OCE）方法，该方法可以对角膜的深度弹性分布进行非接触式评估。 OCE系统将聚焦的吹气装置与相敏光学相干断层扫描（OCT）相结合。低压短时气流用于以微米水平的局部位移加载角膜。具有纳米级灵敏度的相位分辨OCT检测可在扫描线内的各个位置探测诱导的角膜变形，从而提供角膜兰姆波传播的超快速成像。通过频谱分析，振幅谱和相位谱可分别用于估计兰姆波的频率范围和量化波传播。在角膜内选择沿顶部和底部角膜边界的弯曲传播路径，以测量整个深度上主要频率分量上的兰姆波的相速度。我们在离体兔眼上进行的先导实验表明，角膜不同层（包括上皮，前基质，后基质和最内层区域）的不同硬度，证明了这种微型OCE方法用于非接触深度的可行性角膜弹性成像。同样，在角膜中的兰姆波离散度的量化可以导致弹性模量的测量，表明该方法用于定量监测角膜生物力学的潜力。

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  • 来源
    《Optical Elastography and Tissue Biomechanics II》|2015年|932716.1-932716.7|共7页
  • 会议地点 San Francisco CA(US)
  • 作者

    Shang Wang; Kirill V. Larin;

  • 作者单位

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA,Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204, USA;

    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA,Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204, USA;

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