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Vascular wall stress during intravascular optical coherence tomography imaging

机译：血管内光学相干断层扫描成像中的血管壁应力

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摘要

Biomechanical properties of arterial wall is crucial for understanding the changes in the cardiovascular system. Catheters are used during intravascular optical coherence tomography (IVOCT) imaging. The presence of a catheter alters the flow field, pressure distribution and frictional resistance to flow in an artery. In this paper, we first study the transmural stress distribution of the catheterized vessel. COMSOL (COMSOL 4.4) was used to simulate the blood flow induced deformation in a catheterized vessel. Blood is modeled as an incompressible Newtonian fluid. Stress distribution from an three-layer vascular model with an eccentric catheter are simulated, which provides a general idea about the distribution of the displacement and the stress. Optical coherence elastography techniques were then applied to porcine carotid artery samples to look at the deformation status of the vascular wall during saline or water injection. Preliminary simulation results show nonuniform stress distribution in the circumferential direction of the eccentrically catheterized vascular model. Three strain rate methods were tested for intravascular OCE application. The tissue Doppler method has the potential to be further developed to image the vascular wall biomechnical properties in vivo. Although results in this study are not validated quantitatively, the experiments and methods may be valuable for intravascular OCE studies, which may provide important information for cardiovascular disease prevention, diagnosis and treatment.
机译：动脉壁的生物力学特性对于了解心血管系统的变化至关重要。在血管内光学相干断层扫描（IVOCT）成像期间使用导管。导管的存在改变了流场，压力分布和在动脉中流动的摩擦阻力。在本文中，我们首先研究导管插入血管的透壁应力分布。 COMSOL（COMSOL 4.4）用于模拟导尿管中血流引起的变形。血液被建模为不可压缩的牛顿流体。模拟了带有偏心导管的三层血管模型的应力分布，这为位移和应力的分布提供了总体思路。然后将光学相干弹性成像技术应用于猪颈动脉样本，以观察盐水或注水过程中血管壁的变形状态。初步的模拟结果表明，在偏心导尿管血管模型的圆周方向上应力分布不均匀。测试了三种应变率方法用于血管内OCE的应用。组织多普勒方法有潜力进一步发展，以成像体内血管壁的生物力学特性。尽管本研究的结果尚未得到定量验证，但这些实验和方法可能对血管内OCE研究有价值，这可能为心血管疾病的预防，诊断和治疗提供重要信息。

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  • 来源
    《Optical Elastography and Tissue Biomechanics II》|2015年|93270E.1-93270E.5|共5页
  • 会议地点 San Francisco CA(US)
  • 作者

    Cuiru Sun; Victor Yang;

  • 作者单位

    Dept. Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada,Dept. Mechanical Engineering, Tianjin University, Tianjin, China;

    Dept. Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada,Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada,Dept. Neurosurgery, Faculty of Medicine, University of Toronto, Toronto, ON, Canada;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Optical coherence elastography; optical coherence tomography; vascular wall stress; intravascular;

    机译：光学相干弹性成像；光学相干断层扫描；血管壁应力血管内;

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