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首页> 外文会议>Optical Elastography and Tissue Biomechanics III >Combined optical coherence tomography and optical coherence elastography for glomerulonephritis classification
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Combined optical coherence tomography and optical coherence elastography for glomerulonephritis classification

机译：光学相干断层扫描和光学相干弹性成像相结合的肾小球肾炎分类

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摘要

Acute Glomerulonephritis caused by anti-glomerular basement membrane disease has a high mortality due to delayed diagnosis. Thus, an accurate and early diagnosis is critical for preserving renal function. Currently, blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution. Optical coherence tomography (OCT) is a noninvasive imaging technique that provides superior spatial resolution (micron scale) as compared to ultrasound and CT. Pathological changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signal, such as optical attenuation and speckle variance. Moreover, OCT does not rely on ionizing radiation as with CT imaging. In addition to structural changes, the elasticity of the kidney can significantly change due to nephritis. In this work, we utilized OCT to detect the difference in tissue properties between healthy and nephritic murine kidneys. Although OCT imaging could identify the diseased tissue, classification accuracy using only optical metrics was clinically inadequate. By combining optical metrics with elasticity, the classification accuracy improved from 76% to 95%. These results show that OCT combined with OCE can be potentially useful for nephritis detection.
机译：抗肾小球基底膜疾病引起的急性肾小球肾炎因诊断延迟而死亡率很高。因此，准确和早期诊断对于保持肾功能至关重要。当前，基于血液，尿液和组织的诊断可能很耗时，而超声和CT成像的空间分辨率较低。光学相干断层扫描（OCT）是一种非侵入性成像技术，与超声和CT相比，可提供出色的空间分辨率（微米级）。可以基于从OCT信号分析的光学指标（例如光学衰减和斑点变化）来检测组织特性的病理变化。此外，OCT不像CT成像那样依赖电离辐射。除了结构变化之外，由于肾炎，肾脏的弹性也会显着变化。在这项工作中，我们利用OCT来检测健康和肾病鼠肾之间组织特性的差异。尽管OCT成像可以识别出患病的组织，但仅使用光学指标进行分类的准确性在临床上仍然不足。通过将光学指标与弹性相结合，分类精度从76％提高到95％。这些结果表明，OCT与OCE结合可能对肾炎的检测有用。

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  • 来源
    《Optical Elastography and Tissue Biomechanics III》|2016年|97100M.1-97100M.7|共7页
  • 会议地点 San Francisco CA(US)
  • 作者

    Chih-Hao Liu; Yong Du; Manmohan Singh; Chen Wu; Zhaolong Han; Jiasong Li; Qais Mohammadzai; Raksha Raghunathan; Thomas Hsu; Shezaan Noorani; Anthony Chang; Chandra Mohan; Kirill V. Larin;

  • 作者单位

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Pathology, the University of Chicago, 5841 S. Maryland Ave., Chicago, IL, USA 60637;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204;

    Department of Biomedical Engineering, University of Houston, 3605 Cullen Boulevard, Houston, Texas, USA 77204,Department of Laser and Biotechnical Systems, Samara State Aerospace University, Samara, Russia;

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  • 正文语种 eng
  • 中图分类
  • 关键词

    glomerulonephritis; elasticity optical coherence elastography; Young's modulus; elastic wave velocity; optical attenuation; speckle variance;

    机译：肾小球肾炎弹性光学相干弹性成像杨氏模量弹性波速度光学衰减斑点变化;

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