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首页> 外文会议>Optical fibers and sensors for medical diagnostics and treatment applications XVI >Quantitative optical coherence elastography based on fiber-optic probe with integrated Fabry-Perot force sensor
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Quantitative optical coherence elastography based on fiber-optic probe with integrated Fabry-Perot force sensor

机译：基于带集成Fabry-Perot力传感器的光纤探头的定量光学相干弹性成像

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摘要

Optical coherence tomography (OCT) is a versatile imaging technique and has great potential in tissue characterization for breast cancer diagnosis and surgical guidance. In addition to structural difference, cancerous breast tissue is usually stiffer compared to normal adipose breast tissue. However, previous studies on compression optical coherence elastography (OCE) are qualitative rather than quantitative. It is challenging to identify the cancerous status of tissue based on qualitative OCE results obtained from different measurement sessions or from different patients. Therefore, it is critical to develop technique that integrates structural imaging and force sensing, for quantitative elasticity characterization of breast tissue. In this work, we demonstrate a quantitative OCE (qOCE) microsurgery device which simultaneously quantifies force exerted to tissue and measures the resultant tissue deformation. The qOCE system is based on a spectral domain OCT engine operated at 1300 nm and a probe with an integrated Febry-Perot (FP) interferometric cavity at its distal end. The FP cavity is formed by the cleaved end of the lead-in fiber and the end surface of a GRIN lens which allows light to incident into tissue for structural imaging. The force exerted to tissue is quantified by the change of FP cavity length which is interrogated by a fiber-optic common-paths phase resolved OCT system with sub-nanometer sensitivity. Simultaneously, image of the tissue structure is acquired from photons returned from tissue through the GRIN lens. Tissue deformation is obtained through Doppler analysis. Tissue elasticity can be quantified by comparing the force exerted and tissue deformation.
机译：光学相干断层扫描（OCT）是一种通用的成像技术，在乳腺癌的诊断和手术指导的组织表征中具有巨大的潜力。除了结构上的差异外，癌性乳腺组织通常比正常脂肪性乳腺组织更硬。但是，以前对压缩光学相干弹性成像（OCE）的研究是定性的，而不是定量的。根据从不同测量阶段或不同患者获得的定性OCE结果来鉴定组织的癌变状态具有挑战性。因此，开发将结构成像和力感测相结合的技术对于乳腺组织的定量弹性表征至关重要。在这项工作中，我们演示了定量的OCE（qOCE）显微外科手术设备，该设备可以同时量化施加到组织上的力并测量产生的组织变形。 qOCE系统基于在1300 nm处运行的光谱域OCT引擎和在其远端具有集成Febry-Perot（FP）干涉腔的探头。 FP腔由导入光纤的开裂端和GRIN透镜的端面形成，GRIN透镜的端面允许光入射到组织中以进行结构成像。 FP腔长度的变化可量化施加到组织上的力，该变化可通过具有亚纳米灵敏度的光纤共路径相位分辨OCT系统进行询问。同时，从通过GRIN透镜从组织返回的光子中获取组织结构的图像。通过多普勒分析获得组织变形。可以通过比较施加的力和组织变形来量化组织弹性。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Yi Qiu; Yahui Wang; Yiqing Xu; Namas Chandra; James Haorah; Basil Hubbi; Bryan J. Pfister; Xuan Liu;

  • 作者单位

    Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA;

    Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA;

    Department of EEE, the University of Hong Kong, Pokfulam Rd, Hong Kong, China;

    Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA;

    Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA;

    Department of Radiology, New Jersey Medical School, Newark, NJ, 07103, USA;

    Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA;

    Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    OCT; elastography; fiber sensor; imaging;

    机译：华侨城;弹性成像光纤传感器影像学;

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