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首页> 外文会议>Optical fibers and sensors for medical diagnostics and treatment applications XVII >Scintillating fiber optic dosimeters for breast and prostate brachytherapy
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Scintillating fiber optic dosimeters for breast and prostate brachytherapy

机译：闪烁光纤剂量计，用于乳房和前列腺的近距离放射治疗

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摘要

Brachytherapy is a radiotherapy modality where the radioactive material is placed close to the tumor, being a common treatment for skin, breast, gynecological and prostate cancers. These treatments can be of low-dose-rate, using isotopes with mean energy of 30 keV, or high-dose-rate, using isotopes such as ~(192)Ir with a mean energy of 380 keV. Currently these treatments are performed in most cases without in-vivo dosimetry for quality control and quality assurance. We developed a dosimeter using small diameter probes that can be inserted into the patient's body using standard brachytherapy needles. By performing real-time dosimetry in breast and prostate brachytherapy it will be possible to perform real-time dose correction when deviations from the treatment plan are observed. The dosimeter presented in this work was evaluated in-vitro. The studies consisted in the characterization of the dosimeter with 500 μm diameter sensitive probes (with a BCF-12 scintillating optical fiber) using an in-house made gelatin breast phantom with a volume of 566 cm3. A breast brachytherapy treatment was simulated considering a tumor volume of 27 cm3 and a prescribed absolute dose of 5 Gy. The dose distribution was determined by the Inverse Planning Simulated Annealing (IPSA) optimization algorithm (ELEKTA). The dwell times estimated from the experimental measurements are in agreement with the prescribed dwell times, with relative error below 3%. The measured signal-to-noise ratio (SNR) including the stem-effect contribution is below 3%.
机译：近距离放射疗法是一种放射疗法，其中放射性物质放置在靠近肿瘤的地方，是皮肤，乳腺癌，妇科和前列腺癌的常见治疗方法。这些处理可以是使用平均能量为30 keV的同位素进行低剂量率治疗，也可以使用平均能量为380 keV的〜（192）Ir等同位素进行高剂量率治疗。当前，这些治疗在大多数情况下无需进行体内剂量测定即可进行质量控制和质量保证。我们开发了使用小直径探针的剂量计，可以使用标准近距离放射治疗针将其插入患者体内。通过在乳房和前列腺近距离放射治疗中执行实时剂量测定，当观察到与治疗计划的偏差时，可以进行实时剂量校正。在这项工作中介绍的剂量计是体外评估的。研究包括使用自制的明胶乳房假体（容积为566 cm3），使用直径为500μm的灵敏探针（带有BCF-12闪烁光纤）表征剂量计。考虑到肿瘤体积为27 cm3，规定的绝对剂量为5 Gy，模拟了乳房近距离放射治疗。剂量分布是通过逆向规划模拟退火（IPSA）优化算法（ELEKTA）确定的。根据实验测量估计的保压时间与规定的保压时间一致，相对误差低于3％。测得的包括干效应贡献的信噪比（SNR）低于3％。

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  • 来源
  • 会议地点 San Francisco(US)
  • 作者

    L.M. Moutinho; I.F. Castro; H. Freitas; J. Melo; P. Silva; A. Gongalves; L. Peralta; P.J. Rachinhas; P.C.P.S. Simoes; S. Pinto; A. Pereira; J.A.M. Santos; M. Costa; J.F.C.A. Veloso;

  • 作者单位

    I3N, Physics Department, University or Aveiro, 3810-193 Portugal,NU-RISE, Aveiro, Portugal;

    I3N, Physics Department, University or Aveiro, 3810-193 Portugal,NU-RISE, Aveiro, Portugal;

    NU-RISE, Aveiro, Portugal;

    NU-RISE, Aveiro, Portugal;

    NU-RISE, Aveiro, Portugal;

    I3N, Physics Department, University or Aveiro, 3810-193 Portugal;

    Faculdade de Ciencias da Universidade de Lisboa,Laboratorio de Instrumentagao e Fisica Experimental de Particulas, LIP-Lisboa;

    Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal;

    Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal;

    Medical Physics Service and Medical Physics, Radiobiology and Radiation Protection Group, IPO Porto,Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal;

    Medical Physics Service and Medical Physics, Radiobiology and Radiation Protection Group, IPO Porto,Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal;

    Medical Physics Service and Medical Physics, Radiobiology and Radiation Protection Group, IPO Porto,Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal,APNOR - Associagao de Politecnicos do Norte, ICBAS, University of Porto, Porto, Portugal;

    APNOR - Associagao de Politecnicos do Norte;

    I3N, Physics Department, University or Aveiro, 3810-193 Portugal,NU-RISE, Aveiro, Portugal;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    brachytherapy; dosimeter; scintillators; scintillating optical fiber; silicon photomultiplier;

    机译：近距离放射治疗；剂量计闪烁体闪烁光纤硅光电倍增管;

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