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首页> 外文会议>Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI; Progress in Biomedical Optics and Imaging; vol.7 no.6 >Delivery of therapeutic laser light using a singlemode silica fiber for a scanning fiber endoscope system
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Delivery of therapeutic laser light using a singlemode silica fiber for a scanning fiber endoscope system

机译：使用单模石英光纤为扫描光纤内窥镜系统输送治疗用激光

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The feasibility of integrating laser-based therapy using a singlemode fiberoptic delivery system in an endoscopic procedure has been investigated. The maximum transmissible optical power in a high-resolution scanning fiber endoscope system is limited by the requirement for small-core singlemode light propagation, thus impeding the capacity for optical therapies. Since the scanning fiber endoscope can be fabricated from low-cost components, the maximum power capacity of the singlemode optical fiber can be approached in the single use of the medical device. In preparation for future tissue studies, 29.4 micron nominally thick samples of Low Density Poly-Ethylene (LDPE) were used as standardized targets. To model the transient pulse-sample interaction of a scanning fiber endoscope, a pulsed, 50mW, 404nm Coherent Cube™ laser system was used to replicate the conditions present in a scanning fiber endoscope that images by measuring the backscatter of combined red, green, and blue laser illumination. Preliminary tests indicate that thermal damage thresholds in LDPE are 120kW/cm~2. Dwell time and repetition characteristics were investigated and thermal damage thresholds for full-power single pulses was approximately 1ms, using 0.125 NA lens to the LDPE film. The higher-power 405 nm laser diodes are able to be directly modulated so that small regions of interest within the scanned sample can be irradiated for diagnosis (autofluorescence) and therapy (cutting and necrosis). Future studies will integrate the violet laser light with red, green, and blue light for frame-sequential imaging, diagnosis, and therapy.
机译：已经研究了在内窥镜手术中使用单模光纤传输系统集成基于激光的治疗的可行性。高分辨率扫描光纤内窥镜系统中的最大可传输光功率受限于对小芯单模光传播的要求，从而阻碍了光疗的能力。由于扫描光纤内窥镜可以由低成本组件制成，因此单次使用医疗设备就可以达到单模光纤的最大功率容量。在为将来的组织研究做准备时，将29.4微米标称厚度的低密度聚乙烯（LDPE）样品用作标准化目标。为了对扫描光纤内窥镜的瞬态脉冲-样品相互作用进行建模，使用了一个脉冲式50mW 404nm Coherent Cube™激光系统来复制扫描光纤内窥镜中存在的条件，该条件通过测量红色，绿色和绿色组合后向散射来成像蓝色激光照明。初步测试表明，LDPE的热损伤阈值为120kW / cm〜2。使用0.125 NA透镜对LDPE膜进行了研究，研究了停留时间和重复特性，全功率单脉冲的热损伤阈值约为1ms。较高功率的405 nm激光二极管能够直接进行调制，以便可以对扫描样品中的小目标区域进行照射，以进行诊断（自发荧光）和治疗（切割和坏死）。未来的研究将把紫色激光与红色，绿色和蓝色的光集成在一起，以进行帧顺序成像，诊断和治疗。

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