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首页> 外文会议>Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI; Progress in Biomedical Optics and Imaging; vol.7 no.6 >Design and Fabrication of a Disposable, Percutaneous Glucose Sensor
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Design and Fabrication of a Disposable, Percutaneous Glucose Sensor

机译：一次性经皮葡萄糖传感器的设计与制造

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摘要

Sencils™ (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-500mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.
机译：Sencils™（感测纤毛）是化学传感器，具有微创，一次性使用和易读性，可在1-3个月的时间内对体内的各种分析物进行频繁测量。经皮光纤可以精确，可靠地对附着在光纤内部末端的纳米工程聚合物基质中的化学反应进行光子测量。第一Sencils基于在聚乙二醇（PEG）基质中与β环糊精结合的荧光团和伴刀豆球蛋白A（Con A）之间的荧光共振能量转移（FRET）的测量来感应组织葡萄糖。体外实验表明，在0-500mg / dl的生理范围内，两种荧光发射的比率与盐水中葡萄糖的浓度之间具有快速而精确的关系。猪的长期植入已证明具有生物相容性。 Sencil平台可适用于检测组织液中的其他分析物。

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