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首页> 外文会议>Optical interactions with tissue and cells XXVI >Investigation of the formation mechanism and morphology of the features created in the interior of cornea by femtosecond laser pulses
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Investigation of the formation mechanism and morphology of the features created in the interior of cornea by femtosecond laser pulses

机译：飞秒激光脉冲在角膜内部形成特征的形成机理和形态研究

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摘要

Laser assisted corneal surgeries often rely on the nonlinear absorption effect of ultrafast lasers to induce features in the interior of the cornea without affecting the surface. In particular, corneal flap formation in femtosecond assisted Laser-Assisted in situ Keratomileusis (LASIK) is based on the bubble creation. This study focuses on the interaction between the tissue and the femtosecond laser. Interior of cornea is treated with tightly focused femtosecond laser pulses. Due to the nature of the process, heating of the tissue within and around the focal volume is practically instantaneous. The affected region is subject to thermoelastic stress that arises with the steep temperature elevation. To predict the size of the region subject to the morphological changes due to the laser treatment, the temperature field is calculated. Cavitation bubble initiation and expansion process, which acts as precursor to the stress induced tissue trauma, is studied as well. Theoretical findings are compared against experimental results. High-speed camera is utilized to assess the laser treatment process, showing the temporal development of the cavitation bubbles. The results obtained in this study facilitate a better understanding of the effects of femtosecond laser assisted corneal surgeries and help in choosing optimal laser parameters.
机译：激光辅助角膜手术通常依靠超快激光的非线性吸收效应来诱导角膜内部的特征而不影响表面。特别是，飞秒辅助激光辅助原位角膜磨镶术（LASIK）中的角膜瓣形成是基于气泡的产生。这项研究的重点是组织与飞秒激光之间的相互作用。用紧密聚焦的飞秒激光脉冲治疗角膜内部。由于过程的性质，焦点体积内和周围的组织的加热实际上是瞬时的。受影响的区域承受着随着温度急剧升高而产生的热弹性应力。为了预测由于激光处理而经受形态变化的区域的大小，计算温度场。还研究了空化气泡的引发和膨胀过程，该过程是压力引起的组织创伤的先兆。将理论发现与实验结果进行比较。高速相机用于评估激光处理过程，显示空化气泡随时间的发展。这项研究中获得的结果有助于更好地理解飞秒激光辅助角膜手术的效果，并有助于选择最佳激光参数。

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