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首页> 外文会议>Optical methods in developmental biology II >Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain
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Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain

机译：怀孕期间狂饮乙醇会导致小鼠胚胎脑的显着发育延迟

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Consumption of alcohol during pregnancy can be severely detrimental to the development of the brain in fetuses. This study explores the usage of optical coherence tomography (OCT) to the study the effects of maternal consumption of ethanol on brain development in mouse fetuses. On gestational day 14.5, fetuses were collected and fixed in 4% paraformaldehyde. A swept-source OCT (SSOCT) system was used to acquire 3D images of the brain of ethanol-exposed and control fetuses. The volume of right and left brain ventricles were measured and used to compare between ethanol-exposed and control fetuses. A total of 5 fetuses were used for each of the two groups. The average volumes of the right and left ventricles were measured to be 0.35 and 0.15 mm~3 for ethanol-exposed and control fetuses, respectively. The results demonstrated that there is an alcohol-induced developmental delay in mouse fetal brains.
机译：怀孕期间饮酒可能严重损害胎儿大脑的发育。这项研究探索了光学相干断层扫描（OCT）的用途，以研究母体摄入乙醇对小鼠胎儿大脑发育的影响。在妊娠第14.5天，收集胎儿并将其固定在4％多聚甲醛中。扫描源OCT（SSOCT）系统用于获取乙醇暴露和控制胎儿的大脑的3D图像。测量左右脑室的体积，并用于比较暴露于乙醇的胎儿和对照组胎儿。两组共使用5胎。暴露于乙醇的胎儿和对照组胎儿的右心室和左心室的平均体积分别为0.35和0.15 mm〜3。结果表明，小鼠胎儿大脑中存在酒精诱导的发育延迟。

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