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首页> 外文会议>Optical methods for tumor treatment and detection: Mechanisms and techniques in photodynamic therapy XIX >A Fast Heterogeneous Algorithm for Light Fluence Rate for Prostate Photodynamic Therapy
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A Fast Heterogeneous Algorithm for Light Fluence Rate for Prostate Photodynamic Therapy

机译：前列腺光动力疗法光通量率的快速异构算法

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To accurately calculate light fluence rate distribution in prostate photodynamic therapy (PDT), optical heterogeneity has to be taken into account. Previous study has shown that a kernel based on analytic solution of the diffusion equation can perform the calculation with accuracy comparable to Finite-element method. An assumption is made that light fluence rate detected at a point in the medium is affected primarily by the optical properties of points (or elements) on the line between the source and the point. The exponential decay term of the light fluence rate is expressed as an integral of effective attenuation coefficient of each point along the line. The kernel method is first developed for a point source and then extended for a linear source. A linear source is considered being composed of multiple point sources and light fluence rate is summation of the fluence rates generated by the point sources. In this study, we have implemented a fast ray-trace algorithm to substantially speed up the calculation. The kernel calculation is compared with FEM calculation and is examined with light fluence rate measurements. The examination with clinical measurement data shows that calculated fluence rates present similar features in distribution as the measurement, with errors of 30%-70% for the peak fluence rates. We concluded that our heterogeneous algorithm is potentially valuable for light fluence rate optimization during interstitial PDT.
机译：为了在前列腺光动力疗法（PDT）中准确计算光通量率分布，必须考虑光学异质性。先前的研究表明，基于扩散方程解析解的核能够以与有限元法相当的精度执行计算。假定在介质中某个点处检测到的光通量率主要受源和该点之间的线上的点（或元素）的光学特性的影响。光通量率的指数衰减项表示为沿线每个点的有效衰减系数的整数。首先针对点源开发核方法，然后将其扩展为线性源。线性光源被认为是由多个点光源组成，光通量率是由点光源产生的通量率之和。在这项研究中，我们实现了一种快速射线追踪算法，可以大大加快计算速度。将内核计算与FEM计算进行比较，并通过光通量率测量进行检查。使用临床测量数据进行的检查显示，计算出的注量率在分布方面与测量结果相似，峰值注量率的误差为30％-70％。我们得出的结论是，我们的异构算法对于插页式PDT中的光通量速率优化具有潜在的价值。

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