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首页> 外文会议>Optical methods for tumor treatment and detection: Mechanisms and techniques in photodynamic therapy XIX >A heterogeneous optimization algorithm for reacted singlet oxygen for interstitial PDT
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A heterogeneous optimization algorithm for reacted singlet oxygen for interstitial PDT

机译：间隙PDT反应单线态氧的异构优化算法

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Singlet oxygen (~1O_2) is the major cytotoxic agent for type II photodynamic therapy (PDT). The production of ~'O_2 involves the complex reactions among light, oxygen molecule, and photosensitizer. From universal macroscopic kinetic equations which describe the photochemical processes of PDT, the reacted ~1O_2 concentration, [~1O_2]_rx,with cell target can be expressed in a form related to time integration of the product of ~1O_2 quantum yield and the PDT dose rate. The object of this study is to develop optimization procedures that account for the optical heterogeneity of the patient prostate, the tissue photosensitizer concentrations, and tissue oxygenation, thereby enable delivery of uniform reacted singlet oxygen to the gland. We use the heterogeneous optical properties measured for a patient prostate to calculate a light fluence kernel. Several methods are used to optimize the positions and intensities of CDFs. The Cimmino feasibility algorithm, which is fast, linear, and always converges reliably, is applied as a search tool to optimize the weights of the light sources at each step of the iterative selection. Maximum and minimum dose limits chosen for sample points in the prostate constrain the solution for the intensities of the linear light sources. The study shows that optimization of individual light source positions and intensities is feasible for the heterogeneous prostate during PDT. To study how different photosensitizer distributions as well as tissue oxygenation in the prostate affect optimization, comparisons of light fluence rate were made with measured distribution of photosensitizer in prostate under different tissue oxygenation conditions.
机译：单线态氧（〜1O_2）是II型光动力疗法（PDT）的主要细胞毒性剂。 〜'O_2的产生涉及光，氧分子和光敏剂之间的复杂反应。根据描述PDT的光化学过程的通用宏观动力学方程式，与细胞靶标反应的〜1O_2浓度[〜1O_2] _rx可以与〜1O_2量子产率和PDT剂量乘积的时间积分有关的形式表示率。这项研究的目的是开发优化程序，以解决患者前列腺的光学异质性，组织光敏剂浓度和组织氧合作用，从而能够将反应均匀的单线态氧输送至腺体。我们使用为患者前列腺测量的异质光学性质来计算光通量内核。有几种方法可用于优化CDF的位置和强度。快速，线性且始终可靠收敛的Cimmino可行性算法被用作搜索工具，以在迭代选择的每个步骤中优化光源的权重。为前列腺中的样本点选择的最大和最小剂量限制限制了溶液的线性光源强度。研究表明，对于PDT期间的异质前列腺，单个光源位置和强度的优化是可行的。为了研究前列腺中不同的光敏剂分布以及组织氧合如何影响优化，将光通量率与在不同组织氧合条件下测得的前列腺中光敏剂的分布进行了比较。

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