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首页> 外文会议>Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XX >Study of the relationship between light fluence and photodynamic therapy in a homogeneous tissue phantom
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Study of the relationship between light fluence and photodynamic therapy in a homogeneous tissue phantom

机译：同质组织模型中光通量与光动力疗法之间关系的研究

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For the first time, we summarized previous work, representing the mechanism of photodynamic therapy (PDT) and ordering a set of mathematical models. Valid models were devoted to the simulation of PDT process, which involved two major parts, the photodynamic reaction and photothermal effect. The model covered four common lighting modes, which were point light source, collimated light beam, planar light source and linear light source (in vivo optical fiber) of 50mW~400mW various light intensity and energy of 50J-200J. A homogeneous sphere was used as a tissue phantom and different exposure situations were simulated to study the relationship between the light fluence and PDT. The result turned out that low power light with long treatment time was preferred for photodynamic reaction while photothermal effect required high power. In addition, comparison between the results of the continuous light and intermittent light of a point light source was carried out, which validated the experimental results and drew some conclusions of light modulation optimization. Also, by increasing light intensity to the range of 700mW~3W, the photothermal effect of high-intensity light was simulated. The same effect of uniformly distributed gold particles in the tissue was analyzed and discussed.
机译：第一次，我们总结了以前的工作，代表了光动力疗法（PDT）的机理并建立了一组数学模型。有效的模型专门用于PDT过程的模拟，其中涉及两个主要部分，光动力反应和光热效应。该模型涵盖了四种常见的照明模式，分别是点光源，准直光束，平面光源和线性光源（体内光纤），分别具有50mW〜400mW的各种光强度和50J-200J的能量。使用均质球体作为组织体模，并模拟了不同的曝光情况以研究光通量与PDT之间的关系。结果表明，低功率的光具有较长的处理时间是光动力学反应的首选，而光热效应则需要高功率。另外，对点光源的连续光和间歇光进行了比较，验证了实验结果并得出了光调制优化的结论。此外，通过将光强度增加到700mW〜3W的范围，模拟了高强度光的光热效应。分析并讨论了组织中均匀分布的金颗粒的相同作用。

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