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首页> 外文会议>Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques >Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorine e6 photosensitized death of Ehrlich carcinoma cells
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Investigation of the photodynamic properties of some chlorophyll a derivatives: the effect of doxorubicin on the chlorine e6 photosensitized death of Ehrlich carcinoma cells

机译：研究某些叶绿素a衍生物的光动力学特性：阿霉素对Ehrlich癌细胞对氯e6光敏死亡的影响

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Abstract: The photodynamic properties of chlorine e$-6$/ trimethyl ester (E6), methyl pheophorbid a (MPh), and pheophytin a (Ph), in Ehrlich carcinoma cells were investigated both in vitro and in vivo. All above mentioned photosensitizers (PS) induced the photoirradiated death of neoplasm cells. There was an inverse relationship between the hydrophobicity of the PS and its photodynamic activity (less hydrophobic E6 was shown to be most effective PS). According to the data, irradiation of Ehrlich carcinoma cells in the presence of E6 caused a dramatic decrease in ATP level. The latter could be connected with suppression of the intensity of anaerobic glycolysis and consumption of oxygen. It could be supposed that a decrease in ATP level in Ehrlich carcinoma cells is mainly due to the uncoupling of oxidative phosphorylation. At the same time, supplementary addition of doxorubicin (a chemical decreasing the functional activity of mitochondria) to E6 increased both in vitro and in vivo the phototoxicity of E6. The key role of an energetic status of tumor cells in their resistance to the photodynamic action is proposed.!
机译：摘要：体外和体内研究了氯e $ -6 $ /三甲酯（E6），甲基脱镁叶绿酸a（MPh）和脱镁叶绿素a（Ph）的光动力学性质。所有上述光敏剂（PS）诱导肿瘤细胞的光照射死亡。 PS的疏水性与其光动力活性之间存在反比关系（疏水性较小的E6被证明是最有效的PS）。根据数据，在E6存在下照射Ehrlich癌细胞会导致ATP水平急剧下降。后者可能与抑制厌氧糖酵解强度和耗氧有关。可以推测，Ehrlich癌细胞中ATP水平的降低主要是由于氧化磷酸化的解偶联。同时，向E6补充添加阿霉素（降低线粒体功能活性的化学物质）在体内和体外均会增加E6的光毒性。提出了肿瘤细胞的高能状态在其对光动力作用的抗性中的关键作用。

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