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首页> 外文会议>Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques >Photodynamic therapy of pet animals with spontaneously occurring head and neck carcinomas
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Photodynamic therapy of pet animals with spontaneously occurring head and neck carcinomas

机译：自发发生头颈癌的宠物的光动力疗法

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Abstract: Eleven pets with squamous cell carcinomas of the head and neck were treated with PDT using 3.0 mg/kg Photofrin II and a light dose of 300 J/cm$+2$/ at 632 nm. All tumors had measurable disease that was recurrent following at least one surgical removal. Ten of the eleven patients achieved a complete remission (CR). Of the ten animals with CR, two relapsed at 11 or 13 weeks while the other eight maintained their CR. Six animals remain disease free to the present time, with durations of 65, 56, 56, 56, 50 and 13 weeks. One died of unrelated causes at 12 weeks, and a second animal died of metastatic disease at 8 weeks. In these two cases, extensive histologic evaluation of the treated areas failed to demonstrate any evidence of residual tumor. Toxicity to the tumor bed or surrounding normal tissue was minimal. When the tumor was located adjacent to bone of the mandible or maxilla, the bone was at risk to form sequestra (in 3/5 cases). Based on these preliminary results, PDT may have applications for human patients with carcinoma of the head and neck.!
机译：摘要：用3.0 mg / kg Photofrin II和632 nm的光剂量300 J / cm $ + 2 $ /的PDT对11例患有头颈部鳞状细胞癌的宠物进行了PDT处理。所有肿瘤均具有可测量的疾病，至少经过一次手术切除后才复发。 11名患者中有10名达到了完全缓解（CR）。在十只患有CR的动物中，有两只在11或13周时复发，而其他八只则保持了CR。到目前为止，六只动物没有疾病，持续时间为65、56、56、56、50和13周。一只死于无关的原因，在12周时死亡，另一只动物死于转移性疾病，在8周时死亡。在这两种情况下，对治疗区域的广泛组织学评估未能显示出残留肿瘤的任何证据。对肿瘤床或周围正常组织的毒性很小。当肿瘤位于下颌骨或上颌骨的附近时，骨骼就有形成死骨的风险（3/5例）。基于这些初步结果，PDT可能会应用于患有头颈癌的人类患者。

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