Syntheses of porphyrin and chlorin dimers for photodynamic therapy

机译：卟啉和二氢卟酚二聚体的合成用于光动力治疗

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Abstract: Efficient methods for the syntheses of porphyrin and chlorin dimers joined with variable length carbon units, either at meso positions or at $beta@-pyrrolic positions, are described. The in vivo testing results for some of the dimers are also discussed. The main objective of this work is to understand the structure/activity relationships among carbon-carbon linked dimers of porphyrins and chlorins. It is anticipated that this study will assist the authors in designing photosensitizers with required chemical and photochemical properties.!

机译：摘要：描述了高效合成卟啉和二氢卟吩二聚体的方法，这些卟啉和二氢卟酚二聚体在中观位置或在β-吡咯位置上均带有可变长度碳单元。还讨论了某些二聚体的体内测试结果。这项工作的主要目的是了解卟啉和二氢卟酚的碳-碳连接的二聚体之间的结构/活性关系。预计这项研究将帮助作者设计具有所需化学和光化学特性的光敏剂。

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《Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques》|1991年|p.356-361|共6页
会议地点 Los Angeles CA(US)
作者
Ravindra K. Pandey; Univ. of California/Davis; Roswell Park Cancer Ins titute; Davis; CA; USA; M.G. Vicente; Univ. of California/Davis; Davis; CA; USA; Fuu-Yau Shiau; Univ. of California/Davis; Davis; CA; USA; Thomas J. Dougherty; Roswell Park Cancer Insti;
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正文语种 eng
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5. Syntheses of porphyrin and chlorin dimers for photodynamic therapy [C] . Ravindra K. Pandey, M.G. Vicente, Fuu-Yau Shiau, Conference on optical methods for tumor treatment and early diagnosis . 1991

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Syntheses of porphyrin and chlorin dimers for photodynamic therapy

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