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An endoscopic diffuse optical tomographic method with high resolution based on the improved FOCUSS method

机译:基于改进的FOCUSS方法的高分辨率内窥镜漫射光学层析成像方法

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摘要

Endoscopic DOT has the potential to apply to cancer-related imaging in tubular organs. Although the DOT has relatively large tissue penetration depth, the endoscopic DOT is limited by the narrow space of the internal tubular tissue, so as to the relatively small penetration depth. Because some adenocarcinomas including cervical adenocarcinoma are located in deep canal, it is necessary to improve the imaging resolution under the limited measurement condition. To improve the resolution, a new FOCUSS algorithm along with the image reconstruction algorithm based on the effective detection range (EDR) is developed. This algorithm is based on the region of interest (ROI) to reduce the dimensions of the matrix. The shrinking method cuts down the computation burden. To reduce the computational complexity, double conjugate gradient method is used in the matrix inversion. For a typical inner size and optical properties of the cervix-like tubular tissue, reconstructed images from the simulation data demonstrate that the proposed method achieves equivalent image quality to that obtained from the method based on EDR when the target is close the inner boundary of the model, and with higher spatial resolution and quantitative ratio when the targets are far from the inner boundary of the model. The quantitative ratio of reconstructed absorption and reduced scattering coefficient can be up to 70% and 80% under 5mm depth, respectively. Furthermore, the two close targets with different depths can be separated from each other. The proposed method will be useful to the development of endoscopic DOT technologies in tubular organs.
机译:内窥镜DOT有潜力应用于肾小管癌的相关成像。尽管DOT具有相对较大的组织穿透深度,但是内窥镜DOT受到内部管状组织的狭窄空间的限制,从而相对较小的穿透深度。由于一些腺癌包括宫颈腺癌位于深管中,因此有必要在有限的测量条件下提高成像分辨率。为了提高分辨率,开发了一种新的FOCUSS算法以及基于有效检测范围(EDR)的图像重建算法。该算法基于感兴趣区域(ROI)来减小矩阵的尺寸。缩小方法减少了计算负担。为了降低计算复杂度,在矩阵求逆中使用了双共轭梯度法。对于子宫颈样管状组织的典型内部尺寸和光学特性,从模拟数据重建的图像表明,当目标靠近目标的内部边界时,所提出的方法可以获得与基于EDR的方法相同的图像质量。当目标距离模型的内边界较远时,具有较高的空间分辨率和定量比率。在5mm深度下,重建的吸收量和降低的散射系数的定量比分别可达70%和80%。此外,具有不同深度的两个近距离目标可以彼此分离。所提出的方法将对肾小管内窥镜DOT技术的发展有用。

著录项

  • 来源
    《Optical tomography and spectroscopy of tissue XII》|2017年|1005920.1-1005920.12|共12页
  • 会议地点 San Francisco(US)
  • 作者单位

    Tianjin Key Laboratory of Information Sensing Intelligent Control,School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, 300222, P. R. China;

    Breast Imaging Department, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, P.R.C.;

    Tianjin Key Laboratory of Information Sensing Intelligent Control,School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, 300222, P. R. China;

    Tianjin Key Laboratory of Information Sensing Intelligent Control,School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, 300222, P. R. China;

    Tianjin Key Laboratory of Information Sensing Intelligent Control,School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, 300222, P. R. China;

    Tianjin Key Laboratory of Information Sensing Intelligent Control,School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, 300222, P. R. China;

    Tianjin Key Laboratory of Information Sensing Intelligent Control,School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, 300222, P. R. China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    FOCUSS; endoscopic DOT; near-field; image reconstruction algorithm; resolution;

    机译:重点内镜DOT近场;图像重建算法;解析度;

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