Variation of entropic elasticity of DNA-Psoralen complex under UV light

机译：紫外光下DNA-补骨脂素复合物的熵变弹性

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We measure the entropic elasticity of a single λ-DNA molecule and of a single DNA-Psoralen complex by doing stretching experiments with an optical tweezers. Psoralen is a photosensitive drug used in the treatment of many skin diseases, by impeding DNA replication. Psolaren intercalates the DNA and can form crosslinks with pyrimidine basis in opposite strands of DNA, when illuminated with UVA light. As crosslinks form the persistence length of the complex increases, indicating an increase in rigidity of the complex. We study the kinetics of DNA-Psoralen crosslink formation via changes in entropic elasticity of the complex.

机译：我们通过用光镊进行拉伸实验来测量单个λ-DNA分子和单个DNA-补骨脂素复合物的熵弹性。补骨脂素是一种光敏药物，可通过阻止DNA复制而用于治疗许多皮肤疾病。当用UVA照射时，补骨脂素插入DNA中，并可以与嘧啶碱基在DNA的相反链中形成交联。随着交联的形成，复合物的持久长度增加，表明复合物的刚性增加。我们研究了复杂的熵弹性变化的DNA-补骨脂素交联形成的动力学。

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《Optical Trapping and Optical Micromanipulation II》|2005年|P.593011.1-593011.9|共9页
会议地点 San DiegoCA(US)
作者
M. S. Rocha; O. N. Mesquita;
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作者单位

Departamento de Fisica, ICEx, Universidade Federal de Minas Gerais, Caixa Postal 702, Belo Horizonte, CEP 30123-970, MG, Brazil;

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会议组织
原文格式 PDF
正文语种 eng
中图分类应用光学;
关键词
optical tweezers; psoralen; DNA; persistence length;

机译：镊子;补骨脂素; DNA;持续时间;

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Variation of entropic elasticity of DNA-Psoralen complex under UV light

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