A Microfluidic System for Saliva-Based Detection of Infectious Diseases

机译：基于唾液的传染病检测的微流控系统

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摘要

A "lab-on-a-chip" system for detecting bacterial pathogens in oral fluid samples is described. The system comprises: (1) an oral fluid sample collector; (2) a disposable, plastic microfluidic cassette ("chip") for sample processing including immunochromatographic assay with a nitrocellulose lateral flow strip; (3) a platform that controls the cassette operation by providing metered quantities of reagents, temperature, regulation, valve actuation; and (4) a laser scanner to interrogate the lateral flow strip. The microfluidic chip hosts a fluidic network for cell lysis, nucleic acid extraction and isolation, PCR, and labeling of the PCR product with bioconjugated, upconverting phosphor particles for detection on the lateral flow strip.

机译：描述了一种用于检测口腔液体样品中的细菌病原体的“芯片实验室”系统。该系统包括：（1）口腔液样本收集器；（2）用于样品处理的一次性塑料微流控盒（“芯片”），包括使用硝化纤维素侧流试纸进行免疫色谱分析；（3）一个平台，通过提供定量的试剂，温度，调节量，阀门致动来控制盒操作；（4）激光扫描仪，以询问侧向流动条。微流控芯片拥有一个流体网络，用于细胞裂解，核酸提取和分离，PCR以及PCR产物的生物共轭，上转换荧光粉颗粒标记，以便在侧向流动条上进行检测。

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来源
《Oral-Based Diagnostics; Annals of the New York Academy of Sciences; vol.1098》|2006年|429-436|共8页
会议地点 Lake Lanier IslandsGA(US)
作者
ZONGYUAN CHEN; MICHAEL G. MAUK; JING WANG; WILLIAM R. ABRAMS; PAUL L. A. M. CORSTJENS; R. SAM NIEDBALA; DANIEL MALAMUD; HAIM H. BAU;
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作者单位

University of Pennsylvania School of Engineering and Applied Science, Philadelphia, Pennsylvania, USA;

New York University College of Dentistry, New York, New York, USA;

Leiden University Medical Center, Leiden, the Netherlands Department of Chemistry, Lehi;

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原文格式 PDF
正文语种 eng
中图分类诊断学;
关键词
microfluidics; lab-on-a-chip; infectious diseases; diagno-stics; immunochromatography;

机译：微流体芯片实验室传染性疾病;诊断；免疫层析;

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1. Magnetic-Bead-Based Microfluidic Systems for Fast Detection of Infectious Disease: Dengue Virus as an Example [J] . Kang-Yi Lien, Huan-Yao Lei, Gwo-Bin Lee 科儀新知 . 2010,第2期

机译：基于磁珠的微流控系统可快速检测传染病：以登革热病毒为例
2. Microfluidics and Nanotechnology for Detection of Global Infectious Diseases [J] . Damhorst Gregory L., Murtagh Maurine, Rodriguez William R., Proceedings of the IEEE . 2015,第2期

机译：用于检测全球传染病的微流控和纳米技术
3. Influence of infectious disease seasonality on the performance of the outbreak detection algorithm in the China Infectious Disease Automated-alert and Response System [J] . Ruiping Wang, Yonggen Jiang, Xiaoqin Guo, Journal of International Medical Research . 2018,第1期

机译：传染病季节变化对中国传染病自动警报和响应系统中爆发检测算法性能的影响
4. A Microfluidic System for Saliva-Based Detection of Infectious Diseases [C] . ZONGYUAN CHEN, MICHAEL G. MAUK, JING WANG, Conference on Oral-Based Diagnostics . 2007

机译：一种基于唾液的传染病检测的微流体系统
5. Integrated microfluidic bioprocessors for infectious disease detection. [D] . Thaitrong, Numrin. 2010

机译：集成的微流体生物处理器，可用于传染病检测。
6. Influence of infectious disease seasonality on the performance of the outbreak detection algorithm in the China Infectious Disease Automated-alert and Response System [O] . Ruiping Wang, Yonggen Jiang, Xiaoqin Guo, 2018

机译：传染病季节变化对中国传染病自动预警与反应系统爆发检测算法性能的影响
7. Fast infectious diseases diagnostics based on microfluidic biochip system [O] . Qin Huang, Shanqiao Han, Yan Zhang, 2017

机译：基于微流体生物芯片系统的快速传染病诊断

A Microfluidic System for Saliva-Based Detection of Infectious Diseases

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