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首页> 外文会议>Oral-Based Diagnostics; Annals of the New York Academy of Sciences; vol.1098 >Salivary Biomarkers Associated with Alveolar Bone Loss
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Salivary Biomarkers Associated with Alveolar Bone Loss

机译：唾液生物标志物与牙槽骨丢失相关

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摘要

A longitudinal case-control study was performed to measure the association of salivary biomarkers with alveolar bone loss from a sub-sample of 1,256 post-menopausal women enrolled in the Buffalo Women's Health Initiative. From this cohort, 40 subjects with significant alveolar bone loss over a 5-year period were compared to 40 age-matched control subjects having no alveolar bone loss. Several biomarkers were quantitated in saliva collected at baseline by immunoassay. A positive association was noted between alveolar bone loss and salivary concentrations of hepatocyte growth factor, and interleukin-1 beta, while a negative association was noted for alveolar bone loss and salivary osteonectin. This study provides preliminary evidence that several salivary biomarkers measured at baseline may serve to predict future alveolafbone loss.
机译：进行了一项纵向病例对照研究，以从布法罗妇女健康倡议中纳入的1,256名绝经后妇女的子样本中测量唾液生物标志物与牙槽骨丢失的关系。从该队列中，将40位在5年内牙槽骨骨量明显减少的受试者与40位年龄相匹配的无牙槽骨骨量减少的对照受试者进行比较。通过免疫测定在基线收集的唾液中定量了几种生物标志物。牙槽骨损失与唾液中肝细胞生长因子和白细胞介素-1β的浓度呈正相关，而牙槽骨损失与唾液骨连接素之间呈负相关。这项研究提供了初步的证据，即在基线时测得的几种唾液生物标志物可能有助于预测将来的肺泡小骨丢失。

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