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首页> 外文会议>Oral-Based Diagnostics; Annals of the New York Academy of Sciences; vol.1098 >Saliva-Based Diagnostics Using 16S rRNA Microarrays and Microfluidics
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Saliva-Based Diagnostics Using 16S rRNA Microarrays and Microfluidics

机译：使用16S rRNA芯片和微流控技术进行基于唾液的诊断

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摘要

The development of a diagnostic system based on DNA microarrays for rapid identification and enumeration of microbial species in the oral cavity is described. This system uses gel-based microarrays with immobilized probes designed within a phylogenetic framework that provides for comprehensive microbial monitoring. Understanding the community structure in the oral cavity is a necessary foundation on which to understand the breadth and depth of different microbial communities in the oral cavity and their role in acute and systemic disease. Our ultimate goal is to develop a diagnostic device to identify individuals at high risk for oral disease, and thereby reduce its prevalence and therefore the economic burden associated with treatment. This article discusses recent improvements of our system in reducing diffusional constraints in order to provide more rapid and accurate measurements of the microbial composition of saliva.
机译：描述了基于DNA微阵列的诊断系统的开发，该系统可快速识别和枚举口腔中的微生物。该系统使用基于凝胶的微阵列，该微阵列具有在系统发育框架内设计的固定探针，可提供全面的微生物监测。了解口腔中的群落结构是了解口腔中不同微生物群落的广度和深度及其在急性和全身性疾病中的作用的必要基础。我们的最终目标是开发一种诊断设备，以识别口腔疾病高危人群，从而降低其患病率，从而降低与治疗相关的经济负担。本文讨论了我们系统在减少扩散限制方面的最新改进，以便提供唾液中微生物组成的更快速，准确的测量结果。

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