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首页> 外文会议>Organic semiconductors in sensors and bioelectronics II >Sniffing out Cancer in the Breath: Detection of non-polar volatile Compounds through Carrier Scattering in Random Networks of Carbon Nanotubes
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Sniffing out Cancer in the Breath: Detection of non-polar volatile Compounds through Carrier Scattering in Random Networks of Carbon Nanotubes

机译：嗅出呼吸中的癌症：通过碳纳米管随机网络中的载流子散射检测非极性挥发性化合物

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摘要

Exhaled breath of cancer patients contains certain nonpolar volatile organic compounds (VOCs) which are not present in the breath of a healthy person. An electronic nose composed of an array of random network (RN) of carbon nanotube (CNT) sensors could in principle detect cancer from breath, but the notoriously low sensitivity of CNT sensors to nonpolar VOCs limits their accuracy. We have achieved a marked improvement of the RN-CNT chemiresistors' response to the nonpolar VOCs found in the breath of lung cancer patients by functionalizing them with different types of nonpolymeric organic films as well as discontinuous films composed of sponge-like wires of hexa-peri-hexabenzocoronene (HBC) molecules. By monitoring the changes in conductance, work function and organic film thickness during exposure we show that the enhanced sensitivity of the functionalized RN-CNTs to nonpolar cancer biomarkers stems from carrier scattering induced by swelling of the organic film. Based on these findings, we show that an array of RN-CNT sensors can discriminate between the VOCs found in the breath of patients with lung cancer and in healthy controls. Hence, controlling the carrier scattering in RN-CNTs via deliberate functionalization with suitable organic films could become an important factor in the design of sensors for nonpolar VOCs, which have hitherto been difficult to trace. The results presented here are an important step towards the development of a robust, cost effective electronic nose for sniffing out nonpolar VOCs as biomarkers for cancer in patients' breath.
机译：癌症患者的呼气中含有某些非极性挥发性有机化合物（VOC），这些化合物在健康人的呼吸中不存在。从原理上讲，由碳纳米管（CNT）传感器的随机网络（RN）阵列组成的电子鼻可以从呼吸中检测出癌症，但众所周知，CNT传感器对非极性VOC的敏感性低，限制了其准确性。我们通过使用不同类型的非聚合有机膜以及由海绵状六六维金属丝组成的不连续膜对它们进行功能化，从而显着改善了RN-CNT化学传感器对肺癌患者呼吸中发现的非极性VOC的反应。六苯并六氢呋喃（HBC）分子。通过监测电导率，功函数和有机膜厚度在暴露过程中的变化，我们表明功能化RN-CNT对非极性癌症生物标志物的敏感性提高是由于有机膜溶胀引起的载流子散射。基于这些发现，我们显示出一系列RN-CNT传感器可以区分在肺癌患者的呼吸和健康对照中发现的VOC。因此，通过用合适的有机膜进行有意的功能化来控制RN-CNT中的载流子散射可能成为设计非极性VOC的传感器的重要因素，迄今为止，这种传感器很难追踪。本文介绍的结果是朝着开发出坚固耐用，具有成本效益的电子鼻迈出的重要一步，该电子鼻用于嗅探非极性VOC作为患者呼吸道中癌症的生物标记。

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