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首页> 外文会议>Pacific Symposium on Biocomputing 2004; Jan 6-10, 2004; Hawaii, USA >EXTENSIVE SEARCH FOR DISCRIMINATIVE FEATURES OF ALTERNATIVE SPLICING
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EXTENSIVE SEARCH FOR DISCRIMINATIVE FEATURES OF ALTERNATIVE SPLICING

机译：替代拼接的区别性特征的广泛搜索

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摘要

Alternative pre-mRNA splicing events can be classified into various types, including cassette, mutually exclusive, alternative 3' splice site, alternative 5' splice site, retained intron. The detection of features of a particular type of alternative splicing events is an important and challenging problem in understanding the mechanism of alternative splicing. In this paper, we consider the problem of finding regulatory sequence patterns, which are specific to a particular type of alternative splicing events, on alternative exons and their flanking introns. For this problem, we have designed various pattern features and evaluated them on the alternative splicing data compiled in Lee's ASAP (Alternative Splicing Annotation Project) database. Through our work, we have succeeded in finding features with practically high accuracies.
机译：备选的mRNA前期剪接事件可分为多种类型，包括盒，互斥，备选的3'剪接位点，备选的5'剪接位点，保留的内含子。特定类型的替代剪接事件的特征的检测在理解替代剪接的机制中是一个重要且具有挑战性的问题。在本文中，我们考虑在替代外显子及其侧翼内含子上发现特定于特定类型的替代剪接事件的调控序列模式的问题。针对这个问题，我们设计了各种图案特征，并根据Lee的ASAP（替代拼接注释项目）数据库中编译的替代拼接数据对它们进行了评估。通过我们的工作，我们成功地找到了精度很高的特征。

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